Evidence map›Paper›PMID 27861825›Full record

ArticleImmunology2017

High Smad7 sustains inflammatory cytokine response in refractory coeliac disease.

Silvia Sedda, Veronica De Simone, Irene Marafini, Gerolamo Bevivino, Roberta Izzo, Omero Alessandro Paoluzi, Alfredo Colantoni, Angela Ortenzi, Paolo Giuffrida, Gino R Corazza and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Expression and function of Smad7 in autoimmune and inflammatory diseases.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  9. Involvement of Smad7 in Inflammatory Diseases of the Gut and Colon Cancer.International journal of molecular sciences · 2021
    Review
  10. Association Between Celiac Disease and Cancer.International journal of molecular sciences · 2020
    Review
  11. Refractory Celiac Disease.Current gastroenterology reports · 2020
    Review
  12. Acute Liver Injury after CClInternational journal of molecular sciences · 2019
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Silvia SeddaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Veronica De SimoneDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Irene MarafiniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Gerolamo BevivinoDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Roberta IzzoDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Omero Alessandro PaoluziDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Alfredo ColantoniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Angela OrtenziDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Paolo GiuffridaFirst Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Gino R CorazzaFirst Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Alessandro VanoliDepartment of Molecular Medicine, San Matteo Hospital, University of Pavia, Pavia, Italy.
Antonio Di SabatinoFirst Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Francesco PalloneDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Giovanni MonteleoneDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITUniversity of Pavia · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Refractory coeliac disease (RCD) is a form of coeliac disease (CD) resistant to gluten-free diet and associated with elevated risk of complications. Many effector cytokines over-produced in the gut of patients with RCD are supposed to amplify the tissue-destructive immune response, but it remains unclear if the RCD-associated mucosal inflammation is sustained by defects in counter-regulatory mechanisms. The aim of the present study was to determine whether RCD-related inflammation is marked by high Smad7, an intracellular inhibitor of transforming growth factor-β

Indexed as

BiopsyCeliac DiseaseDiet, Gluten-FreeDuodenumHumansInflammationInterleukin-6Intestinal MucosaMolecular Targeted TherapyRecurrenceRNA, Small InterferingSignal TransductionSmad7 ProteinTransforming Growth Factor betaTumor Necrosis Factor-alphaInterleukin-6RNA, Small InterferingSmad7 ProteinSMAD7 protein, humanTransforming Growth Factor betaTumor Necrosis Factor-alphagluteninflammationmucosal immune responsetransforming growth factor-β

Identifiers

PMID27861825
PMCPMC5290231
OpenAlexW2555250413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.