Evidence map›Paper›PMID 27861708›Full record

Trial reportJournal of the American Geriatrics Society2017

High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial.

Adit A Ginde, Patrick Blatchford, Keith Breese, Lida Zarrabi, Sunny A Linnebur, Jeffrey I Wallace, Robert S Schwartz

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01102374 (Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents), which is not on this map. Cited by 87 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 19 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01102374 phase2completednot on this map

Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents

TypeinterventionalSponsorUniversity of Colorado, DenverRan2010 to 2016Enrolled107ConditionsRespiratory InfectionArmsHigh Dose Vitamin D, Standard Dose Vitamin D, Placebo, Usual Care
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 19 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
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  6. Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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  14. Guideline
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  20. The Effect of Vitamin DJournal of the American Geriatrics Society · 2026
    Trial

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adit A GindeDepartment of Emergency Medicine, School of Medicine, University of Colorado, Aurora, Colorado.
Patrick BlatchfordDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado.
Keith BreeseDepartment of Emergency Medicine, School of Medicine, University of Colorado, Aurora, Colorado.
Lida ZarrabiDepartment of Emergency Medicine, School of Medicine, University of Colorado, Aurora, Colorado.
Sunny A LinneburDepartment of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado.
Jeffrey I WallaceDivision of Geriatric Medicine, School of Medicine, University of Colorado, Aurora, Colorado.
Robert S SchwartzGeriatric Research, Education and Clinical Center, Eastern Colorado Department of Veterans Affairs, Denver, Colorado.
University of Colorado Denver · USGeriatric Research Education and Clinical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Vitamin D and Immunosenescence in Older Long-Term Care ResidentsK23AG040708 · NIA · UNIVERSITY OF COLORADO DENVER · PI GINDE, ADIT A. · 2011 to 2013
$624k
NCATS NIH HHS UL1 TR001082NIA NIH HHS K23 AG040708
6 · The paper itself

Abstract

objectivesTo determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents.

designRandomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014.

settingColorado long-term care facilities.

participantsLong-term care residents aged 60 and older (n = 107).

interventionThe high-dose group received monthly supplement of vitamin D MEASUREMENTS: The primary outcome was incidence of ARI during the 12-month intervention. Secondary outcomes were falls and fractures, 25-hydroxyvitamin D levels, hypercalcemia, and kidney stones.

resultsParticipants (55 high dose, 52 standard dose) were randomized and included in the final analysis. The high-dose group had 0.67 ARIs per person-year and the standard-dose group had 1.11 (incidence rate ratio (IRR) = 0.60, 95% confidence interval (CI) = 0.38-0.94, P = .02). Falls were more common in the high-dose group (1.47 per person-year vs 0.63 in standard-dose group; IRR = 2.33, 95% CI = 1.49-3.63, P < .001). Fractures were uncommon and similar in both groups (high dose 0.10 vs standard dose 0.19 per person-year; P = .31). Mean trough 25-hydroxyvitamin D levels during the trial were 32. ng/mL in the high-dose group and 25.1 ng/mL in the standard-dose group. There was no hypercalcemia or kidney stones in either group.

conclusionMonthly high-dose vitamin D

Indexed as

Accidental FallsAged, 80 and overAssisted Living FacilitiesCholecalciferolColoradoDose-Response Relationship, DrugDouble-Blind MethodFemaleFractures, BoneHumansMaleRespiratory Tract InfectionsSkilled Nursing FacilitiesVitamin DVitamins25-hydroxyvitamin DCholecalciferolVitamin DVitaminsfallsimmunosenescencenursing homerespiratory infectionvitamin D

Identifiers

PMID27861708
PMCPMC5357189
OpenAlexW2549708057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.