ArticlePloS one2016
An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts.Nutrients · 2021Trial
- Production and functional applications of fructooligosaccharides and their core bioactive components.World journal of microbiology & biotechnology · 2026Review
- Article
- Administration of 1-kestose to beluga reduces intestinal Turicibacter and collagenase gene levels, and blood creatinine levels.The Journal of veterinary medical science · 2025Article
- Alterations in Ileal Microbiota and Fecal Metabolite Profiles of Chickens with Immunity toAnimals : an open access journal from MDPI · 2024Article
- Agarooligosaccharides as a novel concept in prebiotics: selective inhibition ofMicrobiology (Reading, England) · 2024Article
- Co-administration of the prebiotic 1-kestose and the paraprobiotic Lactiplantibacillus plantarum FM8 in magellanic penguins promotes the activity of intestinal Lactobacillaceae and reduces the plc gene levels encoding Clostridium perfringens toxin.The Journal of veterinary medical science · 2024Article
- Dietary supplementation with 1-kestose induces altered locomotor activity and increased striatal dopamine levels with a change in gut microbiota in male mice.Physiological reports · 2023Article
- In children with cow's milk allergy, 1-kestose affects the gut microbiota and reaction threshold.Pediatric research · 2023Article
- Role of microRNAs in the crosstalk between the gut microbiota and intestinal immune system.Bioscience of microbiota, food and health · 2023Review
- Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia.Bioscience of microbiota, food and health · 2021Article
- Small in size, big on taste: Metabolomics analysis of flavor compounds from Philippine garlic.PloS one · 2021Article
- 1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats.Scientific reports · 2020Article
- Activation of butyrate-producing bacteria as well as bifidobacteria in the cat intestinal microbiota by the administration of 1-kestose, the smallest component of fructo-oligosaccharide.The Journal of veterinary medical science · 2020Article
- Comment on Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats.Foods (Basel, Switzerland) · 2020Article
- Kestose supplementation exerts bifidogenic effect within fecal microbiota and increases fecal butyrate concentration in dogs.The Journal of veterinary medical science · 2020Article
- Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats.Foods (Basel, Switzerland) · 2019Article
- Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver.Foods (Basel, Switzerland) · 2019Article
- 1-Kestose, the Smallest Fructooligosaccharide Component, Which Efficiently StimulatesFoods (Basel, Switzerland) · 2018Review
- Intestinal Microbiota Modulation in Obesity-Related Non-alcoholic Fatty Liver Disease.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional food ingredients, including prebiotics, have been ardently developed for improving the intestinal environment. Fructooligosaccarides (FOS), including fructans, are the well researched and commercialized prebiotics. However, to our knowledge, few studies have been conducted on the physiological effects of each component of FOS as prebiotics. 1-Kestose, a component of FOS, is composed of one glucose and two fructose molecules, and is considered as a key prebiotic component in short-chain FOS. In the present study, we examined the effects of dietary 1-kestose using 0.5-5% 1-kestose diets on cecal microbiota composition and cecal contents of short-chain fatty acids and lactate in rats. The findings indicate that dietary 1-kestose induced cecal hypertrophy and alterations in the cecal microbiota composition, including a marked increase in the cell number of Bifidobacterium spp. These alterations were associated with significant increases in acetate and lactate, and a marked increase in butyrate in cecal contents. Furthermore, dietary 1-kestose induced a significant decrease in serum insulin concentration in rats fed 2.5-5% 1-kestose diet. These findings suggest a potential of 1-kestose to be a prebiotic for improving the metabolism of the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.