Evidence map›Paper›PMID 27861606›Full record

ArticlePloS one2016

Predominance of Clostridium difficile Ribotypes 017 and 078 among Toxigenic Clinical Isolates in Southern Taiwan.

Yuan-Pin Hung, I-Hsiu Huang, Hsiao-Ju Lin, Bo-Yang Tsai, Hsiao-Chieh Liu, Hsiu-Chuan Liu, Jen-Chieh Lee, Yi-Hui Wu, Pei-Jane Tsai, Wen-Chien Ko

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An Update onToxins · 2022
    Review
  6. Temporal Variations in Patterns ofAntibiotics (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  9. Enterotoxic Clostridia:Microbiology spectrum · 2019
    Review
  10. Emerging microbes & infections · 2019
    Review
  11. Tropical medicine and infectious disease · 2018
    Review
  12. Article
  13. Lauric Acid Is an Inhibitor ofFrontiers in microbiology · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan-Pin HungDepartment of Internal Medicine, Tainan Hospital, Ministry of Health & Welfare, Tainan, Taiwan.
I-Hsiu HuangDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsiao-Ju LinDepartment of Internal Medicine, Tainan Hospital, Ministry of Health & Welfare, Tainan, Taiwan.
Bo-Yang TsaiDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsiao-Chieh LiuDepartment of Internal Medicine, Tainan Hospital, Ministry of Health & Welfare, Tainan, Taiwan.
Hsiu-Chuan LiuDepartment of Experiment and Diagnosis, Tainan Hospital, Ministry of Health & Welfare, Tainan, Taiwan.
Jen-Chieh LeeDepartment of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Yi-Hui WuDepartment of Internal Medicine, E-da Hospital, Kaohsiung, Taiwan.
Pei-Jane TsaiDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wen-Chien KoDepartment of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribotypes and toxin genotypes of clinical C. difficile isolates in Taiwan are rarely reported. A prospective surveillance study from January 2011 to January 2013 was conducted at the medical wards of a district hospital in southern Taiwan. Of the first toxigenic isolates from 120 patients, 68 (56.7%) of 120 isolates possessed both tcdA and tcdB. Of 52 (43.3%) with tcdB and truncated tcdA (tcdA-/tcdB+), all were ribotype 017 and none had binary toxin or tcdC deletion. Eighteen (15%) toxigenic isolates harbored binary toxins (cdtA and cdtB) and all had tcdC deletion, including Δ39 (C184T) deletion (14 isolates), Δ18 in-frame deletion (3 isolates), and Δ18 (Δ117A) deletion (1 isolate). Eleven of 14 isolates with Δ39 (C184T) deletion belonged to the ribotype 078 family, including ribotype 127 (6 isolates), ribotype 126 (4 isolates), and ribotype 078 (1 isolate). Among 8 patients with consecutive C. difficile isolates, these isolates from 6 (75%) patients were identical, irrespective of the presence or absence of diarrhea, suggestive of persistent fecal carriage or colonization. In conclusion in southern Taiwan, ribotype 017 isolates with a tcdA-/tcdB+ genotype were not uncommon and of C. difficile isolates with binary toxin, the ribotype 078 family was predominant.

Indexed as

GenotypeRibotypingAnti-Bacterial AgentsBacterial ToxinsClostridioides difficileEnterocolitis, PseudomembranousEnterotoxinsHumansMicrobial Sensitivity TestsRepetitive Sequences, Nucleic AcidSequence DeletionTaiwanAnti-Bacterial AgentsBacterial ToxinsEnterotoxins

Identifiers

PMID27861606
PMCPMC5115699

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.