ArticlePloS one2016
Heart Rate Dependence of the Pulmonary Resistance x Compliance (RC) Time and Impact on Right Ventricular Load.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study).JHLT open · 2026Article
- Pulmonary artery compliance is associated with mortality but lacks predictive utility.JHLT open · 2026Article
- The resistance-compliance relationship at low pulmonary resistance: Integrating pulmonary wedge pressure into right ventricular load assessment.Physiological reports · 2026Article
- Acute pulmonary vasoreactivity: a simple test revisited in the contemporary era - a narrative review.International journal of cardiology. Heart & vasculature · 2026Review
- Empiric Pulmonary Arterial Compliance Reflects the Resistance-Compliance Relationship and Predicts Mortality in Pulmonary Hypertension.Pulmonary circulation · 2025Article
- The pulmonary resistance-compliance relationship: Real or mathematical artifact?Physiological reports · 2025Article
- The golden ratio in the pulmonary circulation in patients with heart failure and cardiogenic shock.Physiological reports · 2025Article
- Case Series Evaluating the Relationship of SGLT2 Inhibition to Pulmonary Artery Pressure and Non-Invasive Cardiopulmonary Parameters in HFpEF/HFmrEF Patients-A Pilot Study.Sensors (Basel, Switzerland) · 2025Article
- The Pulmonary Artery Pulsatility Index Provides No Additional Prognostic Information in Pediatric Pulmonary Arterial Hypertension.Children (Basel, Switzerland) · 2024Article
- Insights Into Differences in Pulmonary Hemodynamics in Hispanic Patients With Pulmonary Arterial Hypertension.Cardiology research · 2024Article
- Reply to VanderpoolAmerican journal of respiratory and critical care medicine · 2023Article
- Hemodynamic indices in pulmonary hypertension: a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- RC time (resistance × compliance) is related to residual symptom after pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.International journal of cardiology. Heart & vasculature · 2022Article
- Pressure-based estimation of right ventricular ejection fraction.ESC heart failure · 2022Article
- Prediction, prevention, and management of right ventricular failure after left ventricular assist device implantation: A comprehensive review.Frontiers in cardiovascular medicine · 2022Review
- Defining end-systolic pressure for single-beat estimation of right ventricle-pulmonary artery coupling: simple… but not really.ERJ open research · 2021Article
- Letter by Tedford et al Regarding Article, "Effective Arterial Elastance in the Pulmonary Arterial Circulation: Derivation, Assumptions, and Clinical Applications".Circulation. Heart failure · 2020Article
- A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept.The European respiratory journal · 2020Article
- Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.Blood advances · 2019Article
- Effects of Percutaneous LVAD Support on Right Ventricular Load and Adaptation.Journal of cardiovascular translational research · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe effect of heart rate (HR) and body surface area (BSA) on pulmonary RC time and right ventricular (RV) load is unknown.
methodsTo determine the association of HR and BSA with the pulmonary RC time and measures of RV load, we studied three large patient cohorts including subjects with 1) known or suspected pulmonary arterial hypertension (PAH) (n = 1008), 2) pulmonary hypertension due to left heart disease (n = 468), and 3) end-stage heart failure with reduced ejection fraction (n = 150). To corroborate these associations on an individual patient level, we performed an additional analysis using high-fidelity catheters in 22 patients with PAH undergoing right atrial pacing.
resultsA faster HR inversely correlated with RC time (p<0.01 for all), suggesting augmented RV pulsatile loading. Lower BSA directly correlated with RC time (p<0.05) although the magnitude of this effect was smaller than for HR. With incremental atrial pacing, cardiac output increased and total pulmonary resistance (TPR) fell. However, effective arterial elastance, its mean resistive component (TPR/heart period; 0.60±0.27 vs. 0.79±0.45;p = 0.048), and its pulsatile component (0.27±0.18 vs 0.39±0.28;p = 0.03) all increased at faster HR.
conclusionHeart rate and BSA are associated with pulmonary RC time. As heart rate increases, the pulsatile and total load on the RV also increase. This relationship supports a hemodynamic mechanism for adverse effects of tachycardia on the RV.
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