ArticleJournal of acquired immune deficiency syndromes (1999)2017
Higher Cystatin C Levels Are Associated With Neurocognitive Impairment in Older HIV+ Adults.
Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Plasma Cystatin C Associates With HIV-Associated Neurocognitive Disorder but Is a Poor Diagnostic Marker in Antiretroviral Therapy-Treated Individuals.Journal of acquired immune deficiency syndromes (1999) · 2019Trial
- Identification of distinct HIV reservoir phenotypes and associated immune landscapes.JCI insight · 2026Article
- The Role of Adipokines in the Pathologies of the Central Nervous System.International journal of molecular sciences · 2023Review
- An Exploratory Study of Correlates of Allostatic Load in Older People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda.Journal of neurovirology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe study aims to determine whether cystatin C is associated with HIV disease and HIV-associated neurocognitive impairment (NCI).
methodsParticipants included 124 (HIV+ n = 77; HIV- n = 47) older adults (age ≥ 50 years) examined at the University of California, San Diego HIV Neurobehavioral Research Program. Cystatin C, a biomarker of kidney functioning that has been linked to poor health outcomes, was measured in blood. Participants completed a comprehensive neurocognitive assessment that was used to define both global and domain NCI.
resultsThe HIV+ group had significantly higher cystatin C concentrations than the HIV- group (d = 0.79 P < 0.001). Among HIV+ participants, those with NCI had higher cystatin C concentrations than those without NCI (d = 0.42, P = 0.055), particularly among participants taking tenofovir (d = 0.78, P = 0.004). A receiver-operator characteristic curve identified that cystatin C levels ≥0.75 mg/L were associated with NCI in the HIV+ group. Using this binary variable and including relevant covariates, multivariate modeling confirmed that NCI was associated with higher cystatin C levels (OR = 3.0; P = 0.03).
conclusionsOur results confirm that HIV+ older adults have higher cystatin C than HIV- older adults and further identify that cystatin C may be associated with NCI in this population, particularly if they use tenofovir. This blood biomarker may be a useful clinical tool to identify older HIV+ persons at greater risk for cognitive decline.
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