Trial reportJournal of acquired immune deficiency syndromes (1999)2017
Increased Survival Among HIV-Infected PWID Receiving a Multi-Level HIV Risk and Stigma Reduction Intervention: Results From a Randomized Controlled Trial.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Promoting HIV care continuum outcomes among people who use drugs and alcohol: a systematic review of randomized trials evaluating behavioral HIV care interventions published from 2011 to 2023.BMC public health · 2023Pooled it
- Causes and risk factors of death among people who inject drugs in Indonesia, Ukraine and Vietnam: findings from HPTN 074 randomized trial.BMC infectious diseases · 2023Trial
- Longitudinal Analysis of Depressive Symptoms, Perceived Social Support, and Alcohol Use among HIV-Infected Men Who Inject Drugs in Northern Vietnam.Substance use & misuse · 2020Trial
- A scalable, integrated intervention to engage people who inject drugs in HIV care and medication-assisted treatment (HPTN 074): a randomised, controlled phase 3 feasibility and efficacy study.Lancet (London, England) · 2018Trial
- Stigma Reduction Among African American Women With HIV: UNITY Health Study.Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- A Rapid Review of HIV-Related Stigma-Reduction Randomized Controlled Trials.AIDS and behavior · 2025Review
- Decoding strategies for stigma reduction in substance use disorder: A qualitative synthesis utilizing the theoretical domain and behavior change wheel frameworks.Indian journal of psychiatry · 2025Review
- Interventions for stigma reduction in HIV treatment and prevention designed to enhance antiretroviral uptake and adherence: A systematic review.PLOS global public health · 2025Article
- Unveiling the landscape of antistigma interventions for individuals with substance use disorders: A scoping review.Indian journal of psychiatry · 2024Review
- Can social support mediate stigma and perceived stress in people live with human immunodeficiency virus?AIDS care · 2024Article
- An acceptance-based, intersectional stigma coping intervention for people with HIV who inject drugs-a randomized clinical trial.The Lancet regional health. Europe · 2023Article
- Measuring and Addressing Stigma Within HIV Interventions for People Who Use Drugs: a Scoping Review of Recent Research.Current HIV/AIDS reports · 2022Article
- A community-based intervention to decrease the prevalence of HIV viremia among people who inject drugs in Vietnam.The Lancet regional health. Western Pacific · 2022Article
- Finding the Right Angle: A Geometric Approach to Measuring Intersectional HIV Stigma.AIDS and behavior · 2022Article
- The Role of Alcohol-Related Behavioral Research in the Design of HIV Secondary Prevention Interventions in the Era of Antiretroviral Therapy: Targeted Research Priorities Moving Forward.AIDS and behavior · 2021Article
- Intersecting Stigmas among HIV-Positive People Who Inject Drugs in Vietnam.Health services insights · 2021Article
- Social support modifies the association between hazardous drinking and depression symptoms among ART clients in Vietnam.Drug and alcohol dependence · 2020Article
- Alcohol abstinence stigma and alcohol use among HIV patients in Thai Nguyen, Vietnam.PloS one · 2020Article
- Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam.AIDS and behavior · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveIn Vietnam, where 58% of prevalent HIV cases are attributed to people who inject drugs, we evaluated whether a multi-level intervention could improve care outcomes and increase survival.
methodsWe enrolled 455 HIV-infected males who inject drugs from 32 communes in Thai Nguyen Province. Communes were randomized to a community stigma reduction intervention or standard of care and then within each commune, to an individual enhanced counseling intervention or standard of care, resulting into 4 arms: Arm 1 (standard of care); Arm 2 (community intervention alone); Arm 3 (individual intervention alone); and Arm 4 (community + individual interventions). Follow-up was conducted at 6, 12, 18, and 24 months to assess survival.
resultsOverall mortality was 23% (n = 103/455) more than 2 years. There were no losses to follow-up for the mortality endpoint. Survival at 24 months was different across arms: Arm 4 (87%) vs Arm 1 (82%) vs Arm 2 (68%) vs Arm 3 (73%); log-rank test for comparison among arms: P = 0.001. Among those with CD4 cell count <200 cells/mm and not on antiretroviral therapy at baseline (n = 162), survival at 24 months was higher in Arm 4 (84%) compared with other arms (Arm 1: 61%; Arm 2: 50%; Arm 3: 53%; P-value = 0.002). Overall, Arm 4 (community + individual interventions) had increased uptake of antiretroviral therapy compared with Arms 1, 2, and 3.
conclusionsThis multi-level behavioral intervention seemed to increase survival of HIV-infected participants more than a 2-year period. Relative to the standard of care, the greatest intervention effect was among those with lower CD4 cell counts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.