Evidence map›Paper›PMID 27861238›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2017

Complementary Feeding and Diarrhea and Respiratory Infection Among HIV-Exposed Tanzanian Infants.

Pili Kamenju, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Rodrick R Kisenge, Roland Kupka, Said Aboud, Karim Manji, Christopher Duggan, Wafaie W Fawzi

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pili KamenjuDepartments of *Global Health and Population; †Epidemiology; ‡Biostatistics; §Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; ‖Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; ¶Nutrition Section, United Nations Children's Fund (UNICEF), New York, NY; #Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; and **Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA.
Enju Liu
Ellen Hertzmark
Donna Spiegelman
Rodrick R Kisenge
Roland Kupka
Said Aboud
Karim Manji
Christopher Duggan
Wafaie W Fawzi

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Trial of Vitamins among Children of HIV-infected MothersR01HD043688 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FAWZI, WAFAIE W · 2003 to 2007
$2.7M
Tanzania Infectious Disease Research Training ProgramD43TW007886 · FIC · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2007 to 2018
$1.9M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
FIC NIH HHS D43 TW007886NICHD NIH HHS R01 HD043688NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

objectiveTo examine the association between complementary feeding and risks of diarrhea and acute respiratory infection (ARI) among HIV-exposed infants aged 6-24 months.

designWe prospectively used an Infant and Child Feeding Index (ICFI) to measure complementary feeding practices (breastfeeding status, food consistency, dietary diversity, food group frequency, and meal frequency). We determined the association of ICFI and each of its components with the risk of diarrhea and ARI. Generalized estimating equations were used to estimate the relative risks for morbidity episodes.

settingDar es Salaam, Tanzania. SUBJECTS: A total of 2092 HIV-exposed infants followed from 6 months of age to 24 months of age.

resultsThe ICFI score ranged from 0 to 9; the median score was 6 (interquartile range = 4-7). Low ICFI scores were likely associated with increased risk of dysentery [low vs. high tertile risk ratio (RR): 1.40; 95% confidence interval (CI): 0.93 to 2.10; P for trend = 0.02] and respiratory infection (low vs. high tertile RR: 1.16; 95% CI: 0.96 to 1.41; P for trend = 0.01). Low dietary diversity scores were likely associated with higher risk of dysentery (low vs. high tertile RR: 1.47; 95% CI: 0.92 to 2.35; P for trend = 0.03) and respiratory infection (low vs. high tertile RR: 1.41; 95% CI: 1.13 to 1.76; P for trend = 0.01). Low food consistency scores were associated with higher risk of respiratory infection (RR: 1.77; 95% CI: 1.40 to 2.26; P < 0.01).

conclusionsIn this setting, low ICFI, dietary diversity, and food consistency scores were likely associated with increased risk of diarrhea and ARI among HIV-exposed infants.

Indexed as

Environmental ExposureHIV InfectionsInfant Nutritional Physiological PhenomenaChild, PreschoolDiarrheaDouble-Blind MethodFemaleHumansInfantMaleProspective StudiesRespiratory Tract InfectionsTanzania

Identifiers

PMID27861238
PMCPMC5303142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.