Evidence map›Paper›PMID 27861111›Full record

ArticleRadiology2017

Diagnostic Performance of MR Elastography and Vibration-controlled Transient Elastography in the Detection of Hepatic Fibrosis in Patients with Severe to Morbid Obesity.

Jun Chen, Meng Yin, Jayant A Talwalkar, Jennifer Oudry, Kevin J Glaser, Thomas C Smyrk, Véronique Miette, Laurent Sandrin, Richard L Ehman

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 9 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 9 syntheses or guidelines pooled it, 169 citations in OpenAlex.

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  7. Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019
    Pooled it
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jun ChenFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Meng YinFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Jayant A TalwalkarFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Jennifer OudryFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Kevin J GlaserFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Thomas C SmyrkFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Véronique MietteFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Laurent SandrinFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Richard L EhmanFrom the Departments of Radiology (J.C., M.Y., K.J.G., R.L.E.), Gastroenterology (J.A.T.), and Anatomic Pathology (T.C.S.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Echosens, Paris, France (J.O., V.M., L.S.).
Mayo Clinic · US

Funding

Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)R01EB017197 · NIBIB · MAYO CLINIC ROCHESTER · PI YIN, MENG · 2014 to 2025
$4.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic FibrosisRC1EB010393 · NIBIB · MAYO CLINIC ROCHESTER · PI TALWALKAR, JAYANT A · 2009 to 2010
$925k
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB017197NIBIB NIH HHS R37 EB001981NIBIB NIH HHS RC1 EB010393
6 · The paper itself

Abstract

Purpose To evaluate the diagnostic performance and examination success rate of magnetic resonance (MR) elastography and vibration-controlled transient elastography (VCTE) in the detection of hepatic fibrosis in patients with severe to morbid obesity. Materials and Methods This prospective and HIPAA-compliant study was approved by the institutional review board. A total of 111 patients (71 women, 40 men) participated. Written informed consent was obtained from all patients. Patients underwent MR elastography with two readers and VCTE with three observers to acquire liver stiffness measurements for liver fibrosis assessment. The results were compared with those from liver biopsy. Each pathology specimen was evaluated by two hepatopathologists according to the METAVIR scoring system or Brunt classification when appropriate. All imaging observers were blinded to the biopsy results, and all hepatopathologists were blinded to the imaging results. Examination success rate, interobserver agreement, and diagnostic accuracy for fibrosis detection were assessed. Results In this obese patient population (mean body mass index = 40.3 kg/m

Indexed as

Adipose TissueElasticity Imaging TechniquesFemaleHumansImage Interpretation, Computer-AssistedLiver CirrhosisMaleMiddle AgedObesity, MorbidReproducibility of ResultsSensitivity and SpecificityVibration

Identifiers

PMID27861111
PMCPMC5395333
OpenAlexW2554642866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.