Evidence map›Paper›PMID 27860832›Full record

ReviewAnnual review of physiology2017

Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles.

Jarred M Whitlock, H Criss Hartzell

Abstract readReview
In one paragraph

Review in Annual review of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.

  1. Sex differences in the involvement of skeletal and cardiac muscles in myopathicAmerican journal of physiology. Cell physiology · 2022
    Pooled it
  2. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  3. Article
  4. Review
  5. VapA/Scs2 sustains polarized growth inMicrobial cell (Graz, Austria) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Epsilon Toxin fromToxins · 2024
    Article
  20. Structural basis of closed groove scrambling by a TMEM16 protein.Nature structural & molecular biology · 2024
    Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jarred M WhitlockDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322; email: criss.hartzell@emory.edu.
H Criss HartzellDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322; email: criss.hartzell@emory.edu.
Emory University · US

Funding

Retinal Degeneration and Chloride ChannelsR01EY014852 · NEI · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2003 to 2020
$5.7M
Ion Channel and Lipid Scramblase Functions of Anoctamins: Roles in MyopathyR01AR067786 · NIAMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2015 to 2018
$1.4M
The Role of Anoctamin 6 in Phospholipid Scrambling and Ion Channel ActivityF31GM116556 · NIGMS · EMORY UNIVERSITY · PI WHITLOCK, JARRED MARCUS · 2016 to 2018
$100k
NEI NIH HHS R01 EY014852NIAMS NIH HHS R01 AR067786NIGMS NIH HHS F31 GM116556
6 · The paper itself

Abstract

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body and are implicated in several human diseases. Although the founding members ANO1 (TMEM16A) and ANO2 (TMEM16B) are Ca

Indexed as

AnimalsCalciumCell MembraneChloride ChannelsChloridesExtracellular VesiclesHumansLipidsSignal TransductionCalciumChloride ChannelsChloridesLipidscalciumchannelopathiesexosomesextracellular vesiclesion channelsphospholipid scramblases

Identifiers

PMID27860832
PMCPMC5556385
OpenAlexW2468678680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.