Evidence map›Paper›PMID 27860222›Full record

Trial reportPediatric blood & cancer2017

Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study.

Matthew J Ehrhardt, John T Sandlund, Nan Zhang, Wei Liu, Kirsten K Ness, Nickhill Bhakta, Wassim Chemaitilly, Kevin R Krull, Tara M Brinkman, Deborah B Crom and 8 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05294380 (Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05294380 unknown statusnot on this mapstarted 2021, after this paper: background citation

Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients

TypeobservationalSponsorTrakya UniversityRan2021 to 2022Enrolled60ConditionsSarcopenia, Pediatric Cancer
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Aging in Adult Survivors of Childhood Cancer: Implications for Future Care.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Matthew J EhrhardtDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
John T SandlundDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Nan ZhangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wei LiuDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Nickhill BhaktaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wassim ChemaitillyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Kevin R KrullDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Tara M BrinkmanDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Deborah B CromDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Larry KunDepartment of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
Sue C KasteDepartment of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gregory T ArmstrongDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Daniel M GreenDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Kumar SrivastavaDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Melissa M HudsonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Daniel A MulrooneyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
NCI NIH HHS P30 CA021765NCI NIH HHS U01 CA195547
6 · The paper itself

Abstract

backgroundSurvivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors.

methodChronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data. Multivariable regression was used to investigate associations between sociodemographic characteristics, therapeutic exposures, and outcomes.

resultsSurvivors were a median age of 10 years (range 1-19) at diagnosis and 34 years (range 20-58) at evaluation. Eighty-eight (44%) received radiation, 46 (23%) cranial radiation, and 69 (35%) high-dose methotrexate. Most prevalent CTCAE Grades 3-4 (severe life-threatening) conditions were obesity (35%), hypertension (9%), and impairment of executive function (13%), attention (9%), and memory (4%). Many had impaired strength (48%), flexibility (39%), muscular endurance (36%), and mobility (36%). Demographic and treatment-related factors were associated with the development of individual chronic diseases and functional deficits.

conclusionsClinical evaluation identified a high prevalence of chronic health conditions, neurocognitive deficits, and performance limitations in childhood NHL survivors.

Indexed as

AttentionHypertensionLymphoma, Non-HodgkinMemoryNeurocognitive DisordersObesitySurvivorsAdolescentAdultChildChild, PreschoolChronic DiseaseFemaleFollow-Up StudiesHumansInfantchronic health conditionslate effectsneurocognitivenon-Hodgkin lymphomasurvivorship

Identifiers

PMID27860222
PMCPMC5403569
OpenAlexW2558471755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.