Evidence map›Paper›PMID 27859935›Full record

ArticleGenes, chromosomes & cancer2017

Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.

Lila E Mullany, Jennifer S Herrick, Roger K Wolff, Martha L Slattery

Open access · greenAbstract readComparative Study
In one paragraph

Article in Genes, chromosomes & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Methylation ofCancers · 2021
    Article
  6. Article
  7. Journal of Cancer · 2021
    Article
  8. Genetic variants ofAmerican journal of cancer research · 2021
    Article
  9. Article
  10. MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer.International journal of molecular sciences · 2019
    Article
  11. Article
  12. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2018
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lila E MullanyDepartment of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
Jennifer S HerrickDepartment of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
Roger K WolffDepartment of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
Martha L SlatteryDepartment of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
University of Utah · US

Funding

DIET, ACTIVITY &REPRODUCTION--RISKS FOR RECTAL CANCERR01CA048998 · NCI · UNIVERSITY OF UTAH · PI SLATTERY, MARTHA L · 1991 to 2012
$7.9M
miRNA and colorectal cancer: associations with tumor phenotype and survivalR01CA163683 · NCI · UNIVERSITY OF UTAH · PI SLATTERY, MARTHA L · 2012 to 2017
$6.5M
DIET, ACTIVITY &REPRODUCTION--RISKS FOR RECTAL CANCERU01CA048998 · NCI · UNIVERSITY OF UTAH · PI SLATTERY, MARTHA OR MARTY L · 1997 to 1999
–
NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA163683NCI NIH HHS U01 CA048998
6 · The paper itself

Abstract

We have shown that single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miRNA target genes, and miRNA biogenesis genes minimally contribute to colon cancer risk. It is possible that these SNPs alter survival. We analyzed 565 SNPs in or adjacent to microRNAs, target genes, or biogenesis genes, using 1,115 cases and 1,173 controls; 837 cases had survival information. We tested SNPs for associations with colorectal cancer (CRC) survival using a Cox proportional hazard model adjusting for age, study center, gender, AJCC disease stage, and MSI tumor status. Multiple comparison adjustments were made using the step-down Bonferroni correction. SNPs associated with survival (P

Indexed as

3' Untranslated RegionsAdultAgedBinding SitesBiomarkers, TumorCase-Control StudiesColorectal NeoplasmsFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMicroRNAsMiddle AgedNeoplasm Staging3' Untranslated RegionsBiomarkers, TumorMicroRNAsRNA, Messenger

Identifiers

PMID27859935
PMCPMC6007859
OpenAlexW2554893948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.