ArticleThe Plant journal : for cell and molecular biology2017
Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Article in The Plant journal : for cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Glycoside Hydrolase Family 16 Enzyme RsEG146 From Rhizoctonia solani AG1 IA Induces Cell Death and Triggers Defence Response in Nicotiana tabacum.Molecular plant pathology · 2025Article
- Enzymes in 3D: Synthesis, remodelling, and hydrolysis of cell wall (1,3;1,4)-β-glucans.Plant physiology · 2023Article
- A Surprising Diversity of Xyloglucan Endotransglucosylase/Hydrolase in Wheat: New in Sight to the Roles in Drought Tolerance.International journal of molecular sciences · 2023Article
- Article
- Definition of the Acceptor Substrate Binding Specificity in Plant Xyloglucan Endotransglycosylases Using Computational Chemistry.International journal of molecular sciences · 2022Article
- Reconsidering the function of the xyloglucan endotransglucosylase/hydrolase family.Journal of plant research · 2022Review
- Broad Specific Xyloglucan:Xyloglucosyl Transferases Are Formidable Players in the Re-Modelling of Plant Cell Wall Structures.International journal of molecular sciences · 2022Review
- Genome-wide identification, structural analysis and expression profiles of short internodes related sequence gene family in quinoa.Frontiers in genetics · 2022Article
- Cryogenian Origin and Subsequent Diversification of the Plant Cell-Wall Enzyme XTH Family.Plant & cell physiology · 2021Article
- Ride to cell wall: Arabidopsis XTH11, XTH29 and XTH33 exhibit different secretion pathways and responses to heat and drought stress.The Plant journal : for cell and molecular biology · 2021Article
- Plant Xyloglucan Xyloglucosyl Transferases and the Cell Wall Structure: Subtle but Significant.Molecules (Basel, Switzerland) · 2020Review
- Characterization of FcXTH2, a Novel Xyloglucan Endotransglycosylase/Hydrolase Enzyme of Chilean Strawberry with Hydrolase Activity.International journal of molecular sciences · 2020Article
- A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16).The Journal of biological chemistry · 2019Article
- Genome-Wide Identification and Characterization of Xyloglucan Endotransglycosylase/Hydrolase inGenes · 2019Article
- Genome-Wide Identification, Characterization and Expression Analysis of Xyloglucan Endotransglucosylase/Hydrolase Genes Family in Barley (Molecules (Basel, Switzerland) · 2019Article
- Engineering the acceptor substrate specificity in the xyloglucan endotransglycosylase TmXET6.3 from nasturtium seeds (Tropaeolum majus L.).Plant molecular biology · 2019Article
- The agar-specific hydrolaseThe Journal of biological chemistry · 2019Article
- Localisation and substrate specificities of transglycanases in charophyte algae relate to development and morphology.Journal of cell science · 2018Article
- Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides.Cell reports · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The xyloglucan endotransglycosylase/hydrolase (XTH) gene family encodes enzymes of central importance to plant cell wall remodeling. The evolutionary history of plant XTH gene products is incompletely understood vis-à-vis the larger body of bacterial endoglycanases in Glycoside Hydrolase Family 16 (GH16). To provide molecular insight into this issue, high-resolution X-ray crystal structures and detailed enzyme kinetics of an extant transitional plant endoglucanase (EG) were determined. Functionally intermediate between plant XTH gene products and bacterial licheninases of GH16, Vitis vinifera EG16 (VvEG16) effectively catalyzes the hydrolysis of the backbones of two dominant plant cell wall matrix glycans, xyloglucan (XyG) and β(1,3)/β(1,4)-mixed-linkage glucan (MLG). Crystallographic complexes with extended oligosaccharide substrates reveal the structural basis for the accommodation of both unbranched, mixed-linked (MLG) and highly decorated, linear (XyG) polysaccharide chains in a broad, extended active-site cleft. Structural comparison with representative bacterial licheninases, a xyloglucan endotranglycosylase (XET), and a xyloglucan endohydrolase (XEH) outline the functional ramifications of key sequence deletions and insertions across the phylogenetic landscape of GH16. Although the biological role(s) of EG16 orthologs remains to be fully resolved, the present biochemical and tertiary structural characterization provides key insight into plant cell wall enzyme evolution, which will continue to inform genomic analyses and functional studies across species.
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