ArticleMolecular ecology2017
Population structure and local selection yield high genomic variation in Mimulus guttatus.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 84 citations in OpenAlex.
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- On the causes of correlated genomic ancestry across contrasting hybridization histories in a monkeyflower species pair.bioRxiv : the preprint server for biology · 2026Article
- Introgression and parental conflict shape repeated occurrences of postzygotic isolation in Mimulus.Current biology : CB · 2026Article
- Demographic history of the Jomon people: insights from whole-mitogenome analysis.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2026Article
- Comparative Analyses of Four Reference Genomes Reveal Exceptional Diversity and Weak Linked Selection in the Yellow Monkeyflower (Mimulus guttatus) Complex.Molecular ecology resources · 2025Article
- Heat waves decrease fitness and alter maternal provisioning in natural populations of Mimulus guttatus.American journal of botany · 2025Article
- Fluctuating reproductive isolation and stable ancestry structure in a fine-scaled mosaic of hybridizing Mimulus monkeyflowers.PLoS genetics · 2025Article
- Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).Nature communications · 2024Article
- Weak response to selection on stigma-anther distance in a primarily selfing population of yellow monkeyflower.Proceedings. Biological sciences · 2024Article
- The quantitative genetics of gene expression in Mimulus guttatus.PLoS genetics · 2024Article
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- Demographic consequences of an extreme heat wave are mitigated by spatial heterogeneity in an annual monkeyflower.Ecology and evolution · 2023Article
- The genomic scale of fluctuating selection in a natural plant population.Evolution letters · 2022Article
- Pollinator loss causes rapid adaptive evolution of selfing and dramatically reduces genome-wide genetic variability.Evolution; international journal of organic evolution · 2022Article
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The promise and deceit of genomic selection component analyses.Proceedings. Biological sciences · 2021Article
- Genetic load has potential in large populations but is realized in small inbred populations.Evolutionary applications · 2021Article
- Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.PLoS genetics · 2021Article
- Ancient and recent introgression shape the evolutionary history of pollinator adaptation and speciation in a model monkeyflower radiation (Mimulus section Erythranthe).PLoS genetics · 2021Article
- The population genetics of nonmigratory Allen's Hummingbird (Ecology and evolution · 2021Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Across western North America, Mimulus guttatus exists as many local populations adapted to site-specific environmental challenges. Gene flow between locally adapted populations will affect genetic diversity both within demes and across the larger metapopulation. Here, we analyse 34 whole-genome sequences from the intensively studied Iron Mountain population (IM) in conjunction with sequences from 22 Mimulus individuals sampled from across western North America. Three striking features of these data address hypotheses about migration and selection in a locally adapted population. First, we find very high levels of intrapopulation polymorphism (synonymous π = 0.033). Variation outside of genes is likely even higher but difficult to estimate because excessive divergence reduces the efficiency of read mapping. Second, IM exhibits a significantly positive genomewide average for Tajima's D. This indicates allele frequencies are typically more intermediate than expected from neutrality, opposite the pattern observed in many other species. Third, IM exhibits a distinctive haplotype structure with a genomewide excess of positive associations between rarer alleles at linked loci. This suggests an important effect of gene flow from other Mimulus populations, although a residual effect of population founding might also contribute. The combination of multiple analyses, including a novel tree-based analytic method, illustrates how the balance of local selection, limited dispersal and metapopulation dynamics manifests across the genome. The overall genomic pattern of sequence diversity suggests successful gene flow of divergent immigrant genotypes into IM. However, many loci show patterns indicative of local adaptation, particularly at SNPs associated with chromosomal inversions.
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