Evidence map›Paper›PMID 27859782›Full record

ArticleThe European journal of neuroscience2017

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1

Smijin Soman, Marcus Keatinge, Mahsa Moein, Marc Da Costa, Heather Mortiboys, Alexander Skupin, Sreedevi Sugunan, Michal Bazala, Jacek Kuznicki, Oliver Bandmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  18. Advances in Zebrafish for Diabetes Mellitus with Wound Model.Bioengineering (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Smijin SomanInternational Institute of Molecular and Cell Biology, Warsaw, Poland.
Marcus KeatingeBateson Centre, University of Sheffield, Sheffield, UK.
Mahsa MoeinLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
Marc Da CostaBateson Centre, University of Sheffield, Sheffield, UK.
Heather MortiboysSheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.
Alexander SkupinLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
Sreedevi SugunanInternational Institute of Molecular and Cell Biology, Warsaw, Poland.
Michal BazalaInternational Institute of Molecular and Cell Biology, Warsaw, Poland.
Jacek KuznickiInternational Institute of Molecular and Cell Biology, Warsaw, Poland.
Oliver BandmannBateson Centre, University of Sheffield, Sheffield, UK.
University of Sheffield · GBInternational Institute of Molecular and Cell Biology · PLUniversity of California, San Diego · USUniversity of Luxembourg · LU

Funding

National Biomedical Computation Resource - Competitive Revision SupplementP41GM103426 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2012 to 2019
$14.0M
NIGMS NIH HHS P41 GM103426Parkinson's UK G-1304
6 · The paper itself

Abstract

Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1

Indexed as

AnimalsCalciumCalcium ChannelsDopaminergic NeuronsMitochondriaParkinson DiseaseProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseUp-RegulationVoltage-Dependent Anion Channel 1ZebrafishZebrafish ProteinsCalciumCalcium Channelsmitochondrial calcium uniporterPink1 protein, zebrafishProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseVoltage-Dependent Anion Channel 1Zebrafish ProteinsDanio rerioMICU1Parkinson's diseaseRuthenium red

Identifiers

PMID27859782
PMCPMC5324670
OpenAlexW2555397029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.