ArticleMovement disorders : official journal of the Movement Disorder Society2017
Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction.
Article in Movement disorders : official journal of the Movement Disorder Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 66 citations in OpenAlex.
- Longitudinal Decline in Electrochemical Skin Conductance Reflects Disease Progression in Multiple System Atrophy.European journal of neurology · 2026Article
- Cardiovascular autonomic failure correlates with cutaneous autonomic denervation in PD and MSA.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Neuroimaging and Pathology Biomarkers in Parkinson's Disease and Parkinsonism.Brain sciences · 2026Article
- Thermoregulatory Dysfunction in Parkinson's Disease: Mechanisms, Implications, and Therapeutic Perspectives.Cells · 2025Review
- Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure.Annals of clinical and translational neurology · 2025Observational
- Cutaneous nerve fiber pathology and function in Parkinson's disease and atypical parkinsonism - a cohort study.NPJ Parkinson's disease · 2025Article
- Clinical Assessment of the Autonomic Nervous System.Cardiac electrophysiology clinics · 2024Review
- Autonomic impairment in primary lateral sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.Cerebellum (London, England) · 2024Article
- Infections in the Etiology of Parkinson's Disease and Synucleinopathies: A Renewed Perspective, Mechanistic Insights, and Therapeutic Implications.Journal of Parkinson's disease · 2024Review
- Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist.American journal of clinical dermatology · 2023Review
- Severe distinct dysautonomia in RFC1-related disease associated with Parkinsonism.Journal of the peripheral nervous system : JPNS · 2022Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease: A Morpho-functional Study.Neurology · 2022Article
- Global warming, heat-related illnesses, and the dermatologist.International journal of women's dermatology · 2021Review
- Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group.Movement disorders clinical practice · 2020Review
- An update on MSA: premotor and non-motor features open a window of opportunities for early diagnosis and intervention.Journal of neurology · 2020Review
- Sympathetic outflow to skin predicts central autonomic dysfunction in multiple system atrophy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Diagnosing multiple system atrophy at the prodromal stage.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Is There a Difference in Autonomic Dysfunction Between Multiple System Atrophy Subtypes?Movement disorders clinical practice · 2020Article
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8 authors at 2 institutions in 1 country.
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Abstract
backgroundThe objective of this study was to characterize the degree, pattern, lesion site, and temporal evolution of sudomotor dysfunction in multiple system atrophy (MSA) and to evaluate differences by parkinsonian (MSA-parkinsonism) and cerebellar (MSA-cerebellar) subtypes.
methodsAll cases of MSA evaluated at Mayo Clinic Rochester between 2005 and 2010 with postganglionic sudomotor testing and thermoregulatory sweat test were reviewed. Pattern and lesion site (preganglionic, postganglionic, or mixed) were determined based on thermoregulatory sweat test and postganglionic sudomotor testing.
resultsThe majority of the 232 patients were MSA-parkinsonism (145, 63%). Initial postganglionic sudomotor testing was abnormal in 59%, whereas thermoregulatory sweat test was abnormal in 95% of all patients. MSA-parkinsonism patients were more likely to have an abnormal thermoregulatory sweat test compared with MSA-cerebellar (98% versus 90%, P = 0.006) and had a higher mean percentage of anhidrosis (57%) compared with MSA-cerebellar (48%; P = 0.033). Common anhidrosis patterns were regional (38%) and global (35%). The site of the lesion was preganglionic in 47% and mixed (preganglionic and postganglionic) in 41%. The increase in anhidrosis per year was 6.2% based on 70 repeat thermoregulatory sweat tests performed on 29 patients. The frequency of postganglionic sudomotor abnormalities increased over time.
conclusionsOur findings suggest: (1) sudomotor dysfunction is almost invariably present in MSA and even more common and severe in MSA-parkinsonism than MSA-cerebellar; (2) a preganglionic pattern of sweat loss is common in MSA; however, pre- and postganglionic abnormalities may coexist; and (3) the increasing frequency of postganglionic sudomotor dysfunction over time suggests involvement of postganglionic fibers or sweat glands later in the disease course. © 2016 International Parkinson and Movement Disorder Society.
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