Evidence map›Paper›PMID 27859048›Full record

ArticleEuropean journal of immunology2017

β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice.

Fatima Manzoor, Mark C Johnson, Chengwen Li, R Jude Samulski, Bo Wang, Roland Tisch

Abstract read
In one paragraph

Article in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Prognostic signifcance of IL35 expression in human hepatocellular carcinoma.International journal of clinical and experimental pathology · 2018
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatima ManzoorDepartment of Microbiology & Immunology, Chapel Hill, NC, USA.
Mark C JohnsonDepartment of Microbiology & Immunology, Chapel Hill, NC, USA.
Chengwen LiGene Therapy Center, Chapel Hill, NC, USA.
R Jude SamulskiGene Therapy Center, Chapel Hill, NC, USA.
Bo WangDepartment of Microbiology & Immunology, Chapel Hill, NC, USA.
Roland TischDepartment of Microbiology & Immunology, Chapel Hill, NC, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
BASIC IMMUNE MECHANISMST32AI007273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 1985 to 2020
$5.6M
Combinatorial Beta Cell-Specific Cytokine Therapy to Reverse Type I DiabetesR01DK103546 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2015 to 2018
$1.5M
NCI NIH HHS P30 CA016086NIAID NIH HHS T32 AI007273NIDDK NIH HHS R01 DK103546
6 · The paper itself

Abstract

IL-35 is a recently identified cytokine exhibiting potent immunosuppressive properties. The therapeutic potential and effects of IL-35 on pathogenic T effector cells (Teff) and Foxp3

Indexed as

Genetic TherapyAdoptive TransferAnimalsCell LineDependovirusDiabetes Mellitus, Type 1Disease Models, AnimalEctopic Gene ExpressionFemaleGene ExpressionGenetic VectorsHumansInsulin-Secreting CellsInterleukinsIslets of LangerhansMiceinterleukin-35, mouseInterleukinsRNA, MessengerCytokine immunotherapyIL-35NOD miceType 1 diabetesβ cell

Identifiers

PMID27859048
PMCPMC5233468

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.