Evidence map›Paper›PMID 27859014›Full record

Trial reportClinical and experimental immunology2017

Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.

J P Francis, P C Richmond, D Strickland, S L Prescott, W S Pomat, A Michael, M A Nadal-Sims, C J Edwards-Devitt, P G Holt, D Lehmann and 1 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

J P FrancisPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
P C RichmondSchool of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
D StricklandTelethon Kids Institute, University of Western Australia, Perth, Australia.
S L PrescottSchool of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
W S PomatPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
A MichaelPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
M A Nadal-SimsTelethon Kids Institute, University of Western Australia, Perth, Australia.
C J Edwards-DevittTelethon Kids Institute, University of Western Australia, Perth, Australia.
P G HoltTelethon Kids Institute, University of Western Australia, Perth, Australia.
D LehmannTelethon Kids Institute, University of Western Australia, Perth, Australia.
A H J van den BiggelaarTelethon Kids Institute, University of Western Australia, Perth, Australia.
The Kids Research Institute Australia · AUPapua New Guinea Institute of Medical Research · PGUniversity of Western Australia · AU

Funding

Wellcome Trust
6 · The paper itself

Abstract

In areas where Streptococcus pneumoniae is highly endemic, infants experience very early pneumococcal colonization of the upper respiratory tract, with carriage often persisting into adulthood. We aimed to explore whether newborns in high-risk areas have pre-existing pneumococcal-specific cellular immune responses that may affect early pneumococcal acquisition. Cord blood mononuclear cells (CBMC) of 84 Papua New Guinean (PNG; high endemic) and 33 Australian (AUS; low endemic) newborns were stimulated in vitro with detoxified pneumolysin (dPly) or pneumococcal surface protein A (PspA; families 1 and 2) and compared for cytokine responses. Within the PNG cohort, associations between CBMC dPly and PspA-induced responses and pneumococcal colonization within the first month of life were studied. Significantly higher PspA-specific interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-5, IL-6, IL-10 and IL-13 responses, and lower dPly-IL-6 responses were produced in CBMC cultures of PNG compared to AUS newborns. Higher CBMC PspA-IL-5 and PspA-IL-13 responses correlated with a higher proportion of cord CD4 T cells, and higher dPly-IL-6 responses with a higher frequency of cord antigen-presenting cells. In the PNG cohort, higher PspA-specific IL-5 and IL-6 CBMC responses were associated independently and significantly with increased risk of earlier pneumococcal colonization, while a significant protective effect was found for higher PspA-IL-10 CBMC responses. Pneumococcus-specific cellular immune responses differ between children born in pneumococcal high versus low endemic settings, which may contribute to the higher risk of infants in high endemic settings for early pneumococcal colonization, and hence disease.

Indexed as

Antibodies, BacterialAntigen-Presenting CellsAntigens, BacterialAustraliaBacterial ProteinsCD4-Positive T-LymphocytesCells, CulturedCytokinesFemaleFetal BloodHumansImmunity, CellularInfant, NewbornLeukocytes, MononuclearPapua New GuineaPneumococcal InfectionsAntibodies, BacterialAntigens, BacterialBacterial ProteinsCytokinespneumococcal surface protein AcolonizationnewbornPapua New Guineapneumococcal immunityPspA

Identifiers

PMID27859014
PMCPMC5290304
OpenAlexW2551153811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.