Evidence map›Paper›PMID 27858570›Full record

ArticleJournal of oncology practice2016

Multidisciplinary Optimization of Oral Chemotherapy Delivery at the University of Wisconsin Carbone Cancer Center.

Daniel L Mulkerin, Jason J Bergsbaken, Jessica A Fischer, Mary J Mulkerin, Aaron M Bohler, Mary S Mably

Open access · greenAbstract read
In one paragraph

Article in Journal of oncology practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniel L MulkerinUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Jason J BergsbakenUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Jessica A FischerUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Mary J MulkerinUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Aaron M BohlerUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Mary S MablyUniversity of Wisconsin Carbone Cancer Center; UW Health, Madison, WI; and Riverside Health System, Newport News, VA.
Riverside Regional Medical Center · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

purposeUse of oral chemotherapy is expanding and offers advantages while posing unique safety challenges. ASCO and the Oncology Nursing Society jointly published safety standards for administering chemotherapy that offer a framework for improving oral chemotherapy practice at the University of Wisconsin Carbone Cancer Center.

methodsWith the goal of improving safety, quality, and uniformity within our oral chemotherapy practice, we conducted a gap analysis comparing our practice against ASCO/Oncology Nursing Society guidelines. Areas for improvement were addressed by multidisciplinary workgroups that focused on education, workflows, and information technology. Recommendations and process changes included defining chemotherapy, standardizing patient and caregiver education, mandating the use of comprehensive electronic order sets, and standardizing documentation for dose modification. Revised processes allow pharmacists to review all orders for oral chemotherapy, and they support monitoring adherence and toxicity by using a library of scripted materials.

resultsBetween August 2015 and January 2016, revised processes were implemented across the University of Wisconsin Carbone Cancer Center clinics. The following are key performance indicators: 92.5% of oral chemotherapy orders (n = 1,216) were initiated within comprehensive electronic order sets (N = 1,315), 89.2% compliance with informed consent was achieved, 14.7% of orders (n = 193) required an average of 4.4 minutes review time by the pharmacist, and 100% compliance with first-cycle monitoring of adherence and toxicity was achieved.

conclusionWe closed significant gaps between institutional practice and published standards for our oral chemotherapy practice and experienced steady improvement and sustainable performance in key metrics. We created an electronic definition of oral chemotherapies that allowed us to leverage our electronic health records. We believe our tools are broadly applicable.

Indexed as

Administration, OralAntineoplastic AgentsCancer Care FacilitiesDrug MonitoringDrug Utilization ReviewElectronic Health RecordsHospitals, UniversityHumansMedication AdherenceNational Cancer Institute (U.S.)Patient SafetyPharmacy Service, HospitalUnited StatesAntineoplastic Agents

Identifiers

PMID27858570
PMCPMC5063187
OpenAlexW2531758985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.