ArticleJournal of endocrinological investigation2017
Thiol/disulfide homeostasis in postmenopausal osteoporosis.
Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- The role of thiol-disulfide homeostasis and ischemia-modified albumin in osteosarcopenia.Irish journal of medical science · 2024Article
- Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspectsTurkish journal of medical sciences · 2020Review
- Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach.Oncology letters · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis. MATERIALS AND
methodsA total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups.
resultsThe disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05).
conclusionThiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
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