Evidence map›Paper›PMID 27858325›Full record

SynthesisDigestive diseases and sciences2017

Is POEM the Answer for Management of Spastic Esophageal Disorders? A Systematic Review and Meta-Analysis.

Muhammad Ali Khan, Vivek Kumbhari, Saowanee Ngamruengphong, Amr Ismail, Yen-I Chen, Yamile Haito Chavez, Majidah Bukhari, Richard Nollan, Mohammad Kashif Ismail, Manabu Onimaru and 6 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06290882 (Endoscopic Versus Robotic Myotomy for Treatment of Achalasia), which is not on this map. Cited by 71 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 9 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06290882 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Endoscopic Versus Robotic Myotomy for Treatment of Achalasia (ERMA Trial)

TypeinterventionalSponsorGermans Trias i Pujol HospitalRan2024 to 2027Enrolled144ConditionsAchalasia CardiaArmsRobotic Heller Myotomy, Peroral Endoscopic Myotomy
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 9 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020
    Guideline
  6. Guideline
  7. Pooled it
  8. Pooled it
  9. Guideline
  10. Trial
  11. Trial
  12. Trial
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Spastic Esophageal Disorders-How Much Muscle Should We Cut?Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Article
  19. Peroral endoscopic myotomy in spastic esophageal disorders: Clinical outcomes and optimal approaches.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Muhammad Ali KhanDivision of Gastroenterology and Hepatology, University of Tennessee Health Science Center, Memphis, TN, USA.
Vivek KumbhariDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Saowanee NgamruengphongDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Amr IsmailDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Yen-I ChenDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Yamile Haito ChavezDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Majidah BukhariDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA.
Richard NollanDivision of Gastroenterology and Hepatology, University of Tennessee Health Science Center, Memphis, TN, USA.
Mohammad Kashif IsmailDivision of Gastroenterology and Hepatology, University of Tennessee Health Science Center, Memphis, TN, USA.
Manabu OnimaruDigestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
Valerio BalassoneDigestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
Ahmed SharataGastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, OR, USA.
Lee SwanstromGastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, OR, USA.
Haruhiro InoueDigestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
Alessandro RepiciHumanitas University, Milan, Italy.
Mouen A KhashabDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 1800 Orleans St., Suite 7125 B, Baltimore, MD, 21205, USA. mkhasha1@jhmi.edu.
Johns Hopkins Hospital · USShowa University · JPUniversity of Tennessee Health Science Center · USOregon Clinic · USHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSpastic esophageal disorders (SEDs) include spastic achalasia (type III), diffuse esophageal spasm (DES), and nutcracker/jackhammer esophagus (JH). Per-oral endoscopic myotomy (POEM) has demonstrated efficacy and safety in the treatment of achalasia. Recently, POEM has been indicated for the treatment of SEDs. We conducted a systematic review and meta-analysis to determine the clinical success and safety of POEM in SEDs.

methodsWe searched several databases from 01/01/2007 to 01/10/2016 to identify studies (with five or more patients) on POEM for the treatment of SEDs. Weighted pooled rates (WPRs) for clinical success and adverse events (AEs) were calculated for all SEDs. Clinical success was defined as Eckardt scores of ≤3 and/or improvement in severity of dysphagia based on achalasia disease-specific health-related quality of life questionnaire. The WPRs for clinical success and AEs were analyzed using fixed- or random-effects model based on heterogeneity. The proportionate difference in clinical success and post-procedure adverse event rates among individual types of SEDs was also calculated.

resultsA total of eight observational studies with 179 patients were included in the final analysis. Two studies were of good quality and six were of fair quality based on the National Institutes of Health quality assessment tool. The WPR with 95% confidence interval (CI) for cumulative clinical success of POEM in all SEDs was 87% (78, 93%), I

conclusionPOEM is an effective and safe therapeutic modality for the treatment of spastic esophageal disorders.

Indexed as

Deglutition DisordersEsophageal AchalasiaEsophageal Motility DisordersEsophageal Spasm, DiffuseEsophageal Sphincter, LowerEsophagoscopyEsophagusGastroscopyHumansNatural Orifice Endoscopic SurgeryQuality of LifeTreatment OutcomeAchalasiaDiffuse esophageal spasmJackhammer esophagusPOEMSpastic achalasiaSpastic esophageal disorders

Identifiers

PMID27858325
OpenAlexW2549429662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.