Evidence map›Paper›PMID 27858267›Full record

ArticleJournal of neuro-oncology2017

Correlation of higher levels of soluble TNF-R1 with a shorter survival, independent of age, in recurrent glioblastoma.

Manmeet S Ahluwalia, Stephanie Bou-Anak, Monica E Burgett, Nehaw Sarmey, Divya Khosla, Saurabh Dahiya, Robert J Weil, Eunnyung Bae, Ping Huang, Mary McGraw and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. DUSP8 as a regulator of glioblastoma stem-like cell contribution to tumor vascularization.Journal of experimental & clinical cancer research : CR · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Manmeet S AhluwaliaThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Stephanie Bou-AnakDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB40, Cleveland, OH, 44195, USA.
Monica E BurgettDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB40, Cleveland, OH, 44195, USA.
Nehaw SarmeyThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Divya KhoslaDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB40, Cleveland, OH, 44195, USA.
Saurabh DahiyaThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Robert J WeilThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Eunnyung BaeDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB40, Cleveland, OH, 44195, USA.
Ping HuangDepartment of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB40, Cleveland, OH, 44195, USA.
Mary McGrawThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Lisa M GroveDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Mitchell A OlmanDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Richard A PraysonAnatomic Pathology Laboratory, The Cleveland Clinic, Cleveland, OH, USA.
John H SuhRadiation Oncology, The Cleveland Clinic, Cleveland, OH, USA.
G Yancey GillespieDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Jill Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Amy S NowackiQuantitative Health Sciences, The Cleveland Clinic, Cleveland, OH, USA.
Gene H BarnettThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA.
Candece L GladsonThe Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USA. gladsoc@ccf.org.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · USCase Western Reserve University · USUniversity of Alabama at Birmingham · US

Funding

The Role of FAK-related-non-kinase (FRNK) in Lung FibrosisR01HL085324 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DING, QIANG · 2007 to 2016
$3.9M
Mechanisms Promoting Angiogenesis in GlioblastomaR01CA175120 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2013 to 2017
$1.7M
Myofibroblast differentiation and fibrosis are mediated by TRPV4 mechanosensingR01HL119792 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2014 to 2017
$1.6M
Deranged Coagulation and Fibrinolytic Cascades in Idiopathic Pulmonary FibrosisR01HL103553 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2010 to 2013
$1.6M
Brain Endothelial TNF-R1 Can Function to Inhibit AngiogenesisR01CA152883 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2010 to 2014
$1.6M
Inhibition of Glioma Growth by a Novel MoleculeR01CA127620 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GLADSON, CANDECE L · 2007 to 2011
$1.4M
The Role of Lyn in Glioma Progression and MigrationR01CA109748 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GLADSON, CANDECE L · 2005 to 2009
$1.4M
NCI NIH HHS R01 CA109748NCI NIH HHS R01 CA127620NCI NIH HHS R01 CA152883NCI NIH HHS R01 CA175120NHLBI NIH HHS R01 HL085324NHLBI NIH HHS R01 HL103553NHLBI NIH HHS R01 HL119792
6 · The paper itself

Abstract

The circulating levels of soluble tumor necrosis factor receptor-1 (sTNF-R1) and sTNF-R2 are altered in numerous diseases, including several types of cancer. Correlations with the risk of progression in some cancers, as well as systemic manifestations of the disease and therapeutic side-effects, have been described. However, there is very little information on the levels of these soluble receptors in glioblastoma (GBM). Here, we report on an exploratory retrospective study of the levels of sTNF-Rs in the vascular circulation of patients with GBM. Banked samples were obtained from 112 GBM patients (66 untreated, newly-diagnosed patients and 46 with recurrent disease) from two institutions. The levels of sTNF-R1 in the plasma were significantly lower in patients with newly-diagnosed or recurrent GBM than apparently healthy individuals and correlated with the intensity of expression of TNF-R1 on the tumor-associated endothelial cells (ECs) in the corresponding biopsies. Elevated levels of sTNF-R1 in patients with recurrent, but not newly-diagnosed GBM, were significantly associated with a shorter survival, independent of age (p = 0.02) or steroid medication. In contrast, the levels of circulating sTNF-R2 were significantly higher in recurrent GBM than healthy individuals and there was no significant correlation with expression of TNF-R2 on the tumor-associated ECs or survival time. The results indicate that larger, prospective studies are warranted to determine the predictive value of the levels of sTNF-R1 in patients with recurrent GBM and the factors that regulate the levels of sTNF-Rs in the circulation in GBM patients.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorFemaleGlioblastomaHumansMaleMiddle AgedNeoplasm Recurrence, LocalReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRetrospective StudiesSurvival AnalysisYoung AdultBiomarkers, TumorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIAgeEndothelial cellGlioblastomaSoluble TNF-R1Soluble TNF-R2Survival

Identifiers

PMID27858267
PMCPMC5352462
OpenAlexW2551130813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.