Evidence map›Paper›PMID 27858190›Full record

ArticleCardiovascular drugs and therapy2016

Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction.

Adolf Koudelka, Gabriela Ambrozova, Anna Klinke, Tana Fidlerova, Hana Martiskova, Radek Kuchta, Tanja K Rudolph, Jaroslav Kadlec, Zdenka Kuchtova, Steven R Woodcock and 3 more

Open access · greenAbstract read
In one paragraph

Article in Cardiovascular drugs and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Review
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  11. Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Adolf KoudelkaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic.
Gabriela AmbrozovaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic.
Anna KlinkeInternational Clinical Research Center, St. Anne's University Hospital, Pekarska 53, 656 91, Brno, Czech Republic.
Tana FidlerovaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic.
Hana MartiskovaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic.
Radek KuchtaFaculty of Electrical Engineering and Communication, Brno University of Technology, Technicka 3058/10, 616 00, Brno, Czech Republic.
Tanja K RudolphDepartment of Experimental Cardiology, University Hospital of Cologne, Kerpener Str. 62, 50924, Cologne, Germany.
Jaroslav KadlecFaculty of Electrical Engineering and Communication, Brno University of Technology, Technicka 3058/10, 616 00, Brno, Czech Republic.
Zdenka KuchtovaFaculty of Electrical Engineering and Communication, Brno University of Technology, Technicka 3058/10, 616 00, Brno, Czech Republic.
Steven R WoodcockDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA.
Lukas KubalaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic.
Michaela PekarovaInstitute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, 612 65, Brno, Czech Republic. pekarovam@ibp.cz.
Brno University of Technology · CZCzech Academy of Sciences · CZCzech Academy of Sciences, Institute of Biophysics · CZUniversity Hospital Cologne · DEUniversity of Pittsburgh · USMasaryk University · CZSt. Anne's University Hospital Brno · CZ

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1M
Redox-Derived Pulmonary Anti-Inflammatory MediatorsR01HL064937 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2000 to 2015
$5.6M
Redox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2M
NITRIC OXIDE REGULATION OF VASCULAR OXIDANT INJURYR01HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 1998 to 2007
$3.3M
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9M
NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL058115NHLBI NIH HHS R01 HL064937NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R37 HL058115
6 · The paper itself

Abstract

rationalePulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO

methodsHPAEC were treated with OA-NO

resultsWe discovered that OA-NO

conclusionIn summary, OA-NO

Indexed as

ArginineCell AdhesionCell HypoxiaCell MovementCells, CulturedCell SurvivalEndothelial CellsHumansHypoxia-Inducible Factor 1, alpha SubunitIntercellular Adhesion Molecule-1Interleukin-6Nitric OxideNitric Oxide Synthase Type IIIOleic AcidsPulmonary ArterySTAT3 Transcription FactorArginineHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIL6 protein, humanIntercellular Adhesion Molecule-1Interleukin-6Nitric OxideNitric Oxide Synthase Type IIIN,N-dimethylarginineNOS3 protein, humanOleic AcidsSTAT3 protein, humanSTAT3 Transcription FactorAsymmetric dimethylarginineHuman pulmonary artery endothelial cellHypoxiaNitro-oleic acidPulmonary hypertension

Identifiers

PMID27858190
PMCPMC5490076
OpenAlexW2549701412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.