Evidence map›Paper›PMID 27858165›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2017

NMR study of the effects of some bleomycin C-termini on the structure of a DNA hairpin with the 5'-GC-3' binding site.

Teresa E Lehmann, Sally A Murray, Azure D Ingersoll, Teresa M Reilly, Shelby E Follett, Kevin E Macartney, Mark H Harpster

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Interaction of Zn(II)bleomycin-AJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Teresa E LehmannDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA. tlehmann@uwyo.edu.
Sally A MurrayDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Azure D IngersollDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Teresa M ReillyDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Shelby E FollettDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Kevin E MacartneyDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Mark H HarpsterDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
University of Wyoming · US

Funding

Role of the bleomycin C-termini in DNA binding and toxicity by metallo-bleomycinsR15GM106285 · NIGMS · UNIVERSITY OF WYOMING · PI LEHMANN, TERESA E · 2014 to 2014
$298k
NIGMS NIH HHS R15 GM106285
6 · The paper itself

Abstract

The antibiotics known as bleomycins constitute a family of natural products clinically employed for the treatment of a wide spectrum of cancers. The drug acts as an antitumor agent by virtue of the ability of a metal complex of the antibiotic to cleave DNA. Bleomycins are differentiated by their C-terminal regions. Previous structural studies involving metal-bleomycin-DNA triads have allowed the identification of the bithiazole-(C-terminus substituent) segment in this molecule as the one that most closely interacts with DNA. Three different modes of binding of metallo-bleomycins to DNA (partial or total intercalation of the bithiazole unit between DNA bases, or binding to the minor groove) have been proposed in the literature. The therapeutic use of bleomycin is frequently associated with the development of pulmonary fibrosis. The severity of this side effect has been attributed to the C-terminus of the antibiotic by some researchers. The degree of pulmonary toxicity of bleomycin-A

Indexed as

Anti-Bacterial AgentsBinding SitesBleomycinDNAInverted Repeat SequencesMagnetic Resonance SpectroscopyAnti-Bacterial AgentsBleomycinDNAAnticancer drugDNANMRPulmonary fibrosisStructure–function

Identifiers

PMID27858165
PMCPMC5950717
OpenAlexW2553447202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.