Evidence map›Paper›PMID 27858036›Full record

ArticleNanoscale2016

Fast nucleation for silica nanoparticle synthesis using a sol-gel method.

Chandra K Dixit, Snehasis Bhakta, Ajeet Kumar, Steven L Suib, James F Rusling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Nanoengineered Silica-Based Biomaterials for Regenerative Medicine.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Surface Modification of ZrONanomaterials (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandra K DixitDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA. chandra.kumar_dixit@uconn.edu chandrakumar.dixit@gmail.com.
Snehasis BhaktaDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA. chandra.kumar_dixit@uconn.edu chandrakumar.dixit@gmail.com.
Ajeet KumarChemistry and Biomolecular Science, Clarkson University, Potsdam, New York, USA.
Steven L SuibDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA. chandra.kumar_dixit@uconn.edu chandrakumar.dixit@gmail.com and Institute of Materials Science, University of Connecticut, Storrs, Connecticut, USA.
James F RuslingDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA. chandra.kumar_dixit@uconn.edu chandrakumar.dixit@gmail.com and Institute of Materials Science, University of Connecticut, Storrs, Connecticut, USA and Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA and School of Chemistry, National University of Ireland at Galway, Galway, Ireland.

Funding

Protein Biomarker Arrays for Personalized Treatment of Prostate CancerR01EB016707 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2014 to 2017
$1.4M
Protein Biosensor Arrays Based on NanomaterialsR01EB014586 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2011 to 2014
$1.4M
NIBIB NIH HHS R01 EB014586NIBIB NIH HHS R01 EB016707
6 · The paper itself

Abstract

We have developed a method that for the first time allowed us to synthesize silica particles in 20 minutes using a sol-gel preparation. Therefore, it is critically important to understand the synthesis mechanism and kinetic behavior in order to achieve a higher degree of fine tuning ability during the synthesis. In this study, we have employed our ability to modulate the physical nature of the reaction medium from sol-gel to emulsion, which has allowed us to halt the reaction at a particular time; this has allowed us to precisely understand the mechanism and chemistry of the silica polymerization. The synthesis medium is kept quite simple with tetraethyl orthosilicate (TEOS) as a precursor in an equi-volumetric ethanol-water system and with sodium hydroxide as a catalyst. Synthesis is performed under ambient conditions at 20 °C for 20 minutes followed by phasing out of any unreacted TEOS and polysilicic acid chains via their emulsification with supersaturated water. We have also demonstrated that the developed particles with various sizes can be used as seeds for further particle growth and other applications. Luminol, a chemiluminescent molecule, has been entrapped successfully between the layers of silica and was demonstrated for the chemiluminescence of these particles.

Identifiers

PMID27858036
PMCPMC5137187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.