ArticleInternational journal of applied & basic medical research
Possible role of elevated serum testosterone in pathogenesis of renal stone formation.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Metabolic changes in kidney stone disease.Frontiers in immunology · 2023Pooled it
- Biochemical composition and demographic distribution of kidney stones: a hospital-based cross-sectional study in Eastern Nepal.BMC nephrology · 2026Article
- The Effect of Boron Supplementation on Kidney Stones in Patients With Nephrolithiasis: A Double-Blind Randomized Controlled Trial.Food science & nutrition · 2025Article
- Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2025Article
- Prevalence and Factors Associated with Kidney Stones in the Elderly Iranian Population: Findings from the Ardakan Cohort Study on Aging (ACSA).Archives of Iranian medicine · 2025Article
- Trend analysis of pediatric urolithiasis prevalence from 1990 to 2021 in the BRICS.Frontiers in pediatrics · 2025Article
- Trends in the burden of urolithiasis in China: an analysis from the global burden of disease study 2021.Frontiers in surgery · 2025Article
- The Hidden Link between Polycystic Ovary Syndrome and Kidney Stones: Finding from the Tehran Lipid and Glucose Study (TLGS).Diagnostics (Basel, Switzerland) · 2023Article
- Hormonal and molecular characterization of calcium oxalate stone formers predicting occurrence and recurrence.Urolithiasis · 2023Article
- Relationship Between Serum Testosterone Levels and Kidney Stones Prevalence in Men.Frontiers in endocrinology · 2022Article
- Recent advances on the mechanisms of kidney stone formation (Review).International journal of molecular medicine · 2021Review
- Application of Clavien-Dindo Classification System for Complications of Minimally Invasive Percutaneous Nephrolithotomy.Journal of healthcare engineering · 2021Article
- Decreased Risk of Renal Calculi in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer.International journal of environmental research and public health · 2020Article
- Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal.International journal of microbiology · 2020Article
- Testosterone replacement therapy is associated with an increased risk of urolithiasis.World journal of urology · 2019Article
- Protective effects of finasteride against testosterone-induced calcium oxalate crystallization and crystal-cell adhesion.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- Nephrolithiasis and Polycystic Ovary Syndrome: A Case-Control Study Evaluating Testosterone and Urinary Stone Metabolic Panels.Advances in urology · 2019Article
- Postmenopausal hormone and the risk of nephrolithiasis: A meta-analysis.EXCLI journal · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrolithiasis or renal stone formation occurs with three times higher frequency in males and decreases with age in parallel with the serum testosterone levels, suggesting a role played by male sex hormones. Androgens appear a promotion action and estrogens an inhibitory action on kidney stone formation in several animal models suggesting a study to be carried out to deduce the role played by serum testosterone in the formation of renal stones.
aimThe aim of this study is to define the involvement of serum total testosterone, free testosterone, and dihydrotestosterone in the pathogenesis of urolithiasis in males by comparing the results with healthy males with no present or past history of urolithiasis as controls. MATERIALS AND
methodsA case-control study was undertaken with 108 participants: 78 males diagnosed with urolithiasis and 30 age-matched healthy males.
resultsThe difference between mean age and body mass index of patients and controls were found to be nonsignificant. The total serum testosterone levels, serum dihydrotestosterone levels, were found to be higher in patients when compared to controls, and the difference was found to be significant. The levels of free testosterone and serum estradiol were also found to be higher in urolithiatic patients.
conclusionThe study demonstrates that elevated levels of serum testosterone and serum dihydrotestosterone might be involved in increased incidences of stone formation. The higher levels of estradiol do not seem to be a protective factor in males with urolithiasis with higher serum testosterone levels.
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