ArticleJournal of pediatric neurosciences
Hyponatremia in children with tuberculous meningitis: A hospital-based cohort study.
Article in Journal of pediatric neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A clinical practice guideline for tuberculous meningitis.The Lancet. Infectious diseases · 2026Guideline
- Hyponatremia upon PICU admission: a 10-year retrospective analysis of outcomes and independent prognostic value.BMC pediatrics · 2026Observational
- Prevalence of Electrolyte Abnormality and its Correlation with Clinical Features and Patient Outcomes in Children Admitted to Pediatric Intensive Care Unit of a Resource-Constrained Setting in India.SAGE open medicine · 2025Article
- Article
- Clinical analysis of 103 cases of tuberculous meningitis complicated with hyponatremia in adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Associations of hyponatremia and SIADH with increased mortality, young age and infection parameters in patients with tuberculosis.PloS one · 2022Article
- The Impact of Hyponatremia on the Severity of Childhood Tuberculous Meningitis.Frontiers in neurology · 2021Article
- Tuberculous meningitis in children: Clinical management & outcome.The Indian journal of medical research · 2019Review
- Mechanism, spectrum, consequences and management of hyponatremia in tuberculous meningitis.Wellcome open research · 2019Review
- A Diagnostic Formula for Discrimination of Tuberculous and Bacterial Meningitis Using Clinical and Laboratory Features.Frontiers in cellular and infection microbiology · 2019Article
- Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients.Frontiers in neuroscience · 2019Review
- Hyponatremia is a potential predictor of progression in radiation-induced brain necrosis: a retrospective study.BMC neurology · 2018Article
- A Case Report on Complicated Tuberculous Meningitis.Cureus · 2017Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyponatremia has long been recognized as a potentially serious metabolic consequence of tuberculous meningitis (TBM) occurring in 35-65% of children with the disease. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has for long been believed to be responsible for the majority of cases of hyponatremia in TBM. Cerebral salt wasting syndrome (CSWS) is being increasingly reported as a cause of hyponatremia in some of these children.
aimThis study was done to determine the frequency and causes of hyponatremia in children with TBM.
methodsChildren with newly diagnosed TBM admitted over a 2-year period (January 2009 to December 2010) were included. All patients received anti-tubercular therapy, mannitol for cerebral edema, and steroids. Patients were monitored for body weight, urine output, signs of dehydration, serum electrolytes, blood urea nitrogen, serum creatinine, and urinary sodium. Hyponatremia was diagnosed if the serum sodium was <135 mEq/L. CSWS was diagnosed if there was evidence of excessive urine output, volume depletion, and natriuresis in the presence of hyponatremia. The outcome in terms of survival or death was recorded.
resultsTwenty-nine of 75 children (38.7%) with TBM developed hyponatremia during their hospital stay. In 19 patients, hyponatremia subsided after the discontinuation of mannitol. Ten patients with persistent hyponatremia had CSWS. There were no patients with SIADH.
conclusionsCSWS is an important cause of hyponatremia in children with newly diagnosed TBM. In our patients, it was more commonly seen than SIADH.
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