Evidence map›Paper›PMID 27857753›Full record

ArticleNeural regeneration research2016

Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress.

De-Guo Jiang, Shi-Li Jin, Gong-Ying Li, Qing-Qing Li, Zhi-Ruo Li, Hong-Xia Ma, Chuan-Jun Zhuo, Rong-Huan Jiang, Min-Jie Ye

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights.International journal of molecular sciences · 2025
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  7. BDNF Impact on Biological Markers of Depression-Role of Physical Exercise and Training.International journal of environmental research and public health · 2021
    Review
  8. Article
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  13. Article
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  15. Article
  16. Single Administration of HBK-15-a Triple 5-HTMolecular neurobiology · 2018
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

De-Guo JiangDepartment of Psychiatry, Wenzhou 7 People's Hospital, Wenzhou, Zhejiang Province, China.
Shi-Li JinDepartment of Psychiatry, Second Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Gong-Ying LiDepartment of Psychiatry, Second Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China; Department of Psychiatry, Jining Medical University, Jining, Shandong Province, China.
Qing-Qing LiDepartment of Psychiatry, Jining Medical University, Jining, Shandong Province, China.
Zhi-Ruo LiDepartment of Psychiatry, Second Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Hong-Xia MaDepartment of Psychiatry, Jining Medical University, Jining, Shandong Province, China.
Chuan-Jun ZhuoDepartment of Psychiatry, Wenzhou 7 People's Hospital, Wenzhou, Zhejiang Province, China; Department of Psychiatry, Jining Medical University, Jining, Shandong Province, China; Department of Psychiatry, Tianjin Anding Hospital, Tianjin, China.
Rong-Huan JiangDepartment of Psychological Medicine, Chinese PLA General Hospital, Department of Psychological Medicine, Chinese PLA Medical School, Beijing, China.ORCID 0000-0002-5023-1259
Min-Jie YeThe Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.ORCID 0000-0002-9229-1591
Affiliated Hospital of Jining Medical University · CNJining Medical University · CNChinese PLA General Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies suggest that serotonin (5-HT) might interact with brain-derived neurotrophic factor (BDNF) during the stress response. However, the relationship between 5-HT and BDNF expression under purely psychological stress is unclear. In this study, one hour before psychological stress exposure, the 5-HT1A receptor agonist 8-OH-DPAT or antagonist MDL73005, or the 5-HT2A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress. Immunohistochemistry and

Indexed as

5-HT1A5-HT2Abrain-derived neurotrophic factornerve regenerationneural regenerationpsychological stressserotonin

Identifiers

PMID27857753
PMCPMC5090852
OpenAlexW2525035643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.