ArticleScientific reports2016
Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response.Oncology letters · 2026Article
- Acute anti-obesity treatment with celastrol reduces body weight, cerebral inflammation and metabolic imbalances in mice.Molecular medicine (Cambridge, Mass.) · 2026Article
- Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis.Acta biochimica et biophysica Sinica · 2026Review
- Antibiotic-Mediated Modulation of the Gut Microbiome Identifies Taurine as a Modulator of Adipocyte Function Through TGR5 Signaling.International journal of molecular sciences · 2026Article
- Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway.Journal of diabetes · 2025Article
- Research progress on the role and mechanism of circadian clock geneFrontiers in immunology · 2025Review
- Bibliometric and Visual Analysis of Global Research on Taurine, Creatine, Carnosine, and Anserine with Metabolic Syndrome: From 1992 to 2022.Nutrients · 2023Review
- Effect of circadian rhythm on NAD and other metabolites in human brain.Frontiers in physiology · 2023Article
- Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans.Journal of obesity & metabolic syndrome · 2022Review
- Transcriptome analysis of L-leucine-producing Corynebacterium glutamicum under the addition of trimethylglycine.Amino acids · 2022Article
- Article
- Seafood intake and the development of obesity, insulin resistance and type 2 diabetes.Nutrition research reviews · 2019Review
- Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments.Drug design, development and therapy · 2019Article
- Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease.Oxidative medicine and cellular longevity · 2019Review
- Ameliorative effect of taurine against diabetes and renal-associated disorders (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.