Evidence map›Paper›PMID 27857154›Full record

ArticleScientific reports2016

A van der Waals-like Transition Between Normal and Cancerous Phases in Cell Populations Dynamics of Colorectal Cancer.

Kang Qiu, Li-Fang Wang, Jian Shen, Alssadig A M Yousif, Peng He, Dan-Dan Shao, Xiao-Min Zhang, John B Kirunda, Ya Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang QiuInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Li-Fang WangInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Jian ShenInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Alssadig A M YousifInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Peng HeInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Dan-Dan ShaoInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Xiao-Min ZhangInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
John B KirundaInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.
Ya JiaInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on a deterministic continuous model of cell populations dynamics in the colonic crypt and in colorectal cancer, we propose four combinations of feedback mechanisms in the differentiations from stem cells (SCs) to transit cells (TCs) and then to differentiated cells (DCs), the four combinations include the double linear (LL), the linear and saturating (LS), the saturating and linear (SL), and the double saturating (SS) feedbacks, respectively. The relative fluctuations of the population of SCs, TCs, and DCs around equilibrium states with four feedback mechanisms are studied by using the Langevin method. With the increasing of net growth rate of TCs, it is found that the Fano factors of TCs and DCs go to a peak in a transient phase, and then increase again to infinity in the cases of LS and SS feedbacks. The "up-down-up" characteristic on the Fano factor (like the van der Waals loop) demonstrates that there exists a transient phase between the normal and cancerous phases, our novel findings suggest that the mathematical model with LS or SS feedback might be better to elucidate the dynamics of a normal and abnormal (cancerous) phases.

Indexed as

Cell DifferentiationCell Transformation, NeoplasticColorectal NeoplasmsHumansStem CellsStochastic Processes

Identifiers

PMID27857154
PMCPMC5114675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.