Evidence map›Paper›PMID 27857087›Full record

ArticleBritish dental journal2016

The oral microbiome - an update for oral healthcare professionals.

M Kilian, I L C Chapple, M Hannig, P D Marsh, V Meuric, A M L Pedersen, M S Tonetti, W G Wade, E Zaura

Registry-linked trialOpen access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in British dental journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05999175 (Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control), which is not on this map. Cited by 616 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
616citing papers in PubMed, 6 pooled it
69.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05999175 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Tolerability, Safety of Use, and Efficacy of Cosmetic Products for the Oral Care. In Use Test Under Dentist Control

TypeinterventionalSponsorBiokosmes SrlRan2022 to 2022Enrolled84ConditionsOral Hygiene, Toothbrushing, Dental PlaqueArmsthe toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
3 · Its place in the literature

Who cites it

616 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,198 citations in OpenAlex.

  1. Pooled it
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  6. RETRACTED: Association ofMedicina (Kaunas, Lithuania) · 2024
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  10. Manual vs. interactive power toothbrush on plaque removal and salivary Streptococcus mutans and Lactobacillus casei levels : Single-center, examiner-blinded, randomized clinical trial in orthodontic patients.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024
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  20. Plants (Basel, Switzerland) · 2026
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556 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 7 countries.

M KilianDepartment of Biomedicine, Faculty of Health, Aarhus University, Wilhelm Meyers allé 4, DK-8000, Aarhus C, Denmark.
I L C ChappleSchool of Dentistry, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
M HannigClinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany.
P D MarshSchool of Dentistry, University of Leeds, Leeds, UK.
V MeuricCHU Rennes, EA 1254 Microbiologie Risques infectieux, Université de Rennes 1, Rennes, France.
A M L PedersenSection of Oral Medicine, Clinical Oral Physiology, Oral Pathology and Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
M S TonettiEuropean Research Group on Periodontology, Genova, Italy and Department of Periodontology, The University of Hong Kong, Hong Kong, SAR China.
W G WadeBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
E ZauraDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, the Netherlands.
Aarhus University · DKQueen Mary University of London · GBSaarland University · DEUniversité de Rennes · FRUniversity of Amsterdam · NLUniversity of Birmingham · GBUniversity of Copenhagen · DKUniversity of Hong Kong · HKUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For millions of years, our resident microbes have coevolved and coexisted with us in a mostly harmonious symbiotic relationship. We are not distinct entities from our microbiome, but together we form a 'superorganism' or holobiont, with the microbiome playing a significant role in our physiology and health. The mouth houses the second most diverse microbial community in the body, harbouring over 700 species of bacteria that colonise the hard surfaces of teeth and the soft tissues of the oral mucosa. Through recent advances in technology, we have started to unravel the complexities of the oral microbiome and gained new insights into its role during both health and disease. Perturbations of the oral microbiome through modern-day lifestyles can have detrimental consequences for our general and oral health. In dysbiosis, the finely-tuned equilibrium of the oral ecosystem is disrupted, allowing disease-promoting bacteria to manifest and cause conditions such as caries, gingivitis and periodontitis. For practitioners and patients alike, promoting a balanced microbiome is therefore important to effectively maintain or restore oral health. This article aims to give an update on our current knowledge of the oral microbiome in health and disease and to discuss implications for modern-day oral healthcare.

Indexed as

Dental CariesMicrobiotaOral HealthHumansMouthPeriodontitis

Identifiers

PMID27857087
OpenAlexW2550762460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.