ArticleNature communications2016
Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
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- Divergent evolution of low-complexity regions in the vertebrate CPEB protein family.Frontiers in bioinformatics · 2025Article
- Terminal regions of a protein are a hotspot for low complexity regions and selection.Open biology · 2024Article
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- The Presence of TwoJournal of developmental biology · 2023Article
- Compensatory relationship between low-complexity regions and gene paralogy in the evolution of prokaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- De novo human brain enhancers created by single-nucleotide mutations.Science advances · 2023Article
- Rapid molecular diversification and homogenization of clustered major ampullate silk genes in Argiope garden spiders.PLoS genetics · 2022Article
- Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes.Genes and immunity · 2022Article
- Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions.Biology direct · 2022Article
- The role of zinc in the adaptive evolution of polar phytoplankton.Nature ecology & evolution · 2022Article
- The neuropeptide Y receptor gene repository, phylogeny and comparative expression in allotetraploid common carp.Scientific reports · 2022Article
- Mutation-selection balance and compensatory mechanisms in tumour evolution.Nature reviews. Genetics · 2021Review
- Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families.PLoS computational biology · 2021Article
- Review
- On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.The Journal of biological chemistry · 2020Review
- Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates.BMC evolutionary biology · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein repeats are considered hotspots of protein evolution, associated with acquisition of new functions and novel phenotypic traits, including disease. Paradoxically, however, repeats are often strongly conserved through long spans of evolution. To resolve this conundrum, it is necessary to directly compare paralogous (horizontal) evolution of repeats within proteins with their orthologous (vertical) evolution through speciation. Here we develop a rigorous methodology to identify highly periodic repeats with significant sequence similarity, for which evolutionary rates and selection (dN/dS) can be estimated, and systematically characterize their evolution. We show that horizontal evolution of repeats is markedly accelerated compared with their divergence from orthologues in closely related species. This observation is universal across the diversity of life forms and implies a biphasic evolutionary regime whereby new copies experience rapid functional divergence under combined effects of strongly relaxed purifying selection and positive selection, followed by fixation and conservation of each individual repeat.
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