ArticleNature communications2016
An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Efficient genetic code expansion without host genome modifications.Nature biotechnology · 2025Article
- TK2268 encodes the major aminotransferase involved in the conversion from oxaloacetic acid to aspartic acid inApplied and environmental microbiology · 2025Article
- Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure.Nature communications · 2025Article
- Removal of phosphoglycolate in hyperthermophilic archaea.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A non-carboxylating pentose bisphosphate pathway in halophilic archaea.Communications biology · 2022Article
- Unconventional genetic code systems in archaea.Frontiers in microbiology · 2022Review
- Identification and Enzymatic Analysis of an Archaeal ATP-Dependent Serine Kinase from the Hyperthermophilic ArchaeonJournal of bacteriology · 2021Article
- Heterologous gene expression and characterization of two serine hydroxymethyltransferases from Thermoplasma acidophilum.Extremophiles : life under extreme conditions · 2021Article
- A Structurally Novel Lipoyl Synthase in the Hyperthermophilic Archaeon Thermococcus kodakarensis.Applied and environmental microbiology · 2020Article
- The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production byThe Journal of biological chemistry · 2019Article
- Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants.Nature communications · 2018Article
- SbnI is a free serine kinase that generatesThe Journal of biological chemistry · 2018Article
- Reconstruction of cysteine biosynthesis using engineered cysteine-free enzymes.Scientific reports · 2018Article
- AnApplied and environmental microbiology · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Routes for cysteine biosynthesis are still unknown in many archaea. Here we find that the hyperthermophilic archaeon Thermococcus kodakarensis generates cysteine from serine via O-phosphoserine, in addition to the classical route from 3-phosphoglycerate. The protein responsible for serine phosphorylation is encoded by TK0378, annotated as a chromosome partitioning protein ParB. The TK0378 protein utilizes ADP as the phosphate donor, but in contrast to previously reported ADP-dependent kinases, recognizes a non-sugar substrate. Activity is specific towards free serine, and not observed with threonine, homoserine and serine residues within a peptide. Genetic analyses suggest that TK0378 is involved in serine assimilation and clearly responsible for cysteine biosynthesis from serine. TK0378 homologs, present in Thermococcales and Desulfurococcales, are most likely not ParB proteins and constitute a group of kinases involved in serine utilization.
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