ArticleNeurorehabilitation and neural repair2017
Does Corticospinal Tract Connectivity Influence the Response to Intensive Bimanual Therapy in Children With Unilateral Cerebral Palsy?
Article in Neurorehabilitation and neural repair, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Intensive Neurophysiological Rehabilitation System for children with cerebral palsy: a quasi-randomized controlled trial.BMC neurology · 2023Trial
- Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy.Neurorehabilitation and neural repair · 2021Trial
- Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2018Trial
- Defining Goal-Directed Training for Children with Cerebral Palsy: A Scoping Review and Framework for Implementation.Children (Basel, Switzerland) · 2025Review
- Motor and Sensory Benefits of Mirror Therapy in Children and Adolescents with Unilateral Cerebral Palsy: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- Efficacy of Hand Arm Bimanual Intensive Therapy in Improving Real-World Bimanual Performance and Identifying Predictors for Therapy Success in Children with Unilateral Cerebral Palsy.Physical & occupational therapy in pediatrics · 2025Article
- Longitudinal study of single-pulse TMS in infants with perinatal brain injury: safety and feasibility.Frontiers in human neuroscience · 2025Article
- A Training Program Using Modified Joystick-Operated Ride-on Toys to Complement Conventional Upper Extremity Rehabilitation in Children with Cerebral Palsy: Results from a Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- Single-pulse transcranial magnetic stimulation for assessment of motor development in infants with early brain injury.Expert review of medical devices · 2024Article
- Combining Unimanual and Bimanual Therapies for Children with Hemiparesis: Is There an Optimal Delivery Schedule?Behavioral sciences (Basel, Switzerland) · 2023Article
- Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study.Journal of child neurology · 2023Article
- Anodal Contralesional tDCS Enhances CST Excitability Bilaterally in an Adolescent with Hemiparetic Cerebral Palsy: A Brief Report.Developmental neurorehabilitation · 2023Article
- A ValHeliyon · 2022Article
- Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.Human brain mapping · 2022Article
- Article
- Transcranial magnetic stimulation as a diagnostic and therapeutic tool in cerebral palsy.Postepy psychiatrii neurologii · 2021Review
- Perinatal stroke: mapping and modulating developmental plasticity.Nature reviews. Neurology · 2021Review
- Improvements in Upper Extremity Function Following Intensive Training Are Independent of Corticospinal Tract Organization in Children With Unilateral Spastic Cerebral Palsy: A Clinical Randomized Trial.Frontiers in neurology · 2021Article
- Hand Motor Actions of Children With Cerebral Palsy Are Associated With Abnormal Sensorimotor Cortical Oscillations.Neurorehabilitation and neural repair · 2019Article
- Bimanual Skill Learning after Transcranial Direct Current Stimulation in Children with Unilateral Cerebral Palsy: A Brief Report.Developmental neurorehabilitation · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundReorganization of the corticospinal tract (CST) can occur in unilateral spastic cerebral palsy (USCP). The affected hand can be controlled via (1) typical contralateral projections from the lesioned hemisphere, (2) ipsilateral projections from the nonlesioned hemisphere, and (3) a combination of contralateral and ipsilateral projections (ie, bilateral). Intensive bimanual therapy and constraint-induced movement therapy (CIMT) improve hand function of children with USCP. Earlier it was suggested that the CST connectivity pattern may influence the efficacy of CIMT.
objectiveTo examine whether CST projection pattern influences the efficacy of intensive bimanual therapy in children with USCP.
participantsThirty-three children with USCP (age 8.9 ± 2.6 years, 16 females).
methodsBimanual therapy was provided in a day-camp setting (90 hours). Participants were involved in different bimanual play and functional activities actively engaging both hands. Hand function was tested before and after the intervention with the Jebsen-Taylor Test of Hand Function, Assisting Hand Assessment, ABILHAND-Kids, and the Canadian Occupational Performance Measure. Single-pulse transcranial magnetic stimulation (TMS) was used to determine each child's CST projection pattern (ie, ipsilateral, contralateral, or bilateral).
resultsChildren whose affected hand was controlled only by ipsilateral CST projections had worse Jebsen-Taylor Test of Hand Function and Assisting Hand Assessment scores than children in the contralateral group at baseline. Bimanual hand use and functional hand use was independent of CST projection pattern. After bimanual therapy, improvements on all outcome measures were observed, and these improvements were independent of the CST connectivity pattern.
conclusionThe efficacy of bimanual therapy on hand function in children with USCP appears to be independent of CST connectivity pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.