ArticleProceedings of the National Academy of Sciences of the United States of America2016
Context-dependent memory traces in the crab's mushroom bodies: Functional support for a common origin of high-order memory centers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative Neuroanatomy of Hydrothermal Vent Shrimps: Ecological Differentiation Among Four Alvinocaridid Species.The Journal of comparative neurology · 2026Article
- Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila.BMC biology · 2022Article
- Contextual memory reactivation modulates CaScientific reports · 2022Article
- The velvet worm brain unveils homologies and evolutionary novelties across panarthropods.BMC biology · 2022Article
- Immunocytochemical Localization of Enzymes Involved in Dopamine, Serotonin, and Acetylcholine Synthesis in the Optic Neuropils and Neuroendocrine System of Eyestalks ofFrontiers in neuroanatomy · 2022Article
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- Shells as 'extended architecture': to escape isolation, social hermit crabs choose shells with the right external architecture.Animal cognition · 2020Article
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- Adaptations to extreme conditions.eLife · 2019Article
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- The role of the hippocampus in navigation is memory.Journal of neurophysiology · 2017Review
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The hypothesis of a common origin for the high-order memory centers in bilateral animals is based on the evidence that several key features, including gene expression and neuronal network patterns, are shared across several phyla. Central to this hypothesis is the assumption that the arthropods' higher order neuropils of the forebrain [the mushroom bodies (MBs) of insects and the hemiellipsoid bodies (HBs) of crustaceans] are homologous structures. However, even though involvement in memory processes has been repeatedly demonstrated for the MBs, direct proof of such a role in HBs is lacking. Here, through neuroanatomical and immunohistochemical analysis, we identified, in the crab Neohelice granulata, HBs that resemble the calyxless MBs found in several insects. Using in vivo calcium imaging, we revealed training-dependent changes in neuronal responses of vertical and medial lobes of the HBs. These changes were stimulus-specific, and, like in the hippocampus and MBs, the changes reflected the context attribute of the memory trace, which has been envisioned as an essential feature for the HBs. The present study constitutes functional evidence in favor of a role for the HBs in memory processes, and provides key physiological evidence supporting a common origin of the arthropods' high-order memory centers.
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