ArticleProceedings of the National Academy of Sciences of the United States of America2016
Rapid recovery from the effects of early monocular deprivation is enabled by temporary inactivation of the retinas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Spontaneous recovery from amblyopia following fellow eye vision loss: a systematic review and narrative synthesis.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2024Pooled it
- New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial.Science China. Life sciences · 2022Trial
- A pilot randomized trial of contrast-rebalanced binocular treatment for deprivation amblyopia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020Trial
- The Effect of Combined Patching and Citalopram on Visual Acuity in Adults with Amblyopia: A Randomized, Crossover, Placebo-Controlled Trial.Neural plasticity · 2019Trial
- Schizophrenia-associated glycoprotein Adamtsl3 regulates perineuronal net formation, maintenance, and adult cortical plasticity.Molecular psychiatry · 2026Article
- Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates.Investigative ophthalmology & visual science · 2026Article
- Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation.Frontiers in neuroscience · 2026Article
- Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus.Cell reports · 2025Article
- My 50 Year Odyssey to Develop Behavioral Methods to Let Me See Quickly How Well Kittens See.eNeuro · 2025Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Article
- Comparative analysis of structural modifications induced by monocular retinal inactivation and monocular deprivation in the developing cat lateral geniculate nucleus.The Journal of comparative neurology · 2023Article
- Human deprivation amblyopia: treatment insights from animal models.Frontiers in neuroscience · 2023Article
- Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system.Cerebral cortex communications · 2023Article
- Investigation of the efficacy and safety of retinal inactivation as a treatment for amblyopia in cats.Frontiers in neuroscience · 2023Article
- Metaplasticity: a key to visual recovery from amblyopia in adulthood?Current opinion in ophthalmology · 2022Review
- Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity in mouse V1.Scientific reports · 2022Article
- Multisensory task demands temporally extend the causal requirement for visual cortex in perception.Nature communications · 2022Article
- Article
- Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.Cell reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
A half-century of research on the consequences of monocular deprivation (MD) in animals has revealed a great deal about the pathophysiology of amblyopia. MD initiates synaptic changes in the visual cortex that reduce acuity and binocular vision by causing neurons to lose responsiveness to the deprived eye. However, much less is known about how deprivation-induced synaptic modifications can be reversed to restore normal visual function. One theoretically motivated hypothesis is that a period of inactivity can reduce the threshold for synaptic potentiation such that subsequent visual experience promotes synaptic strengthening and increased responsiveness in the visual cortex. Here we have reduced this idea to practice in two species. In young mice, we show that the otherwise stable loss of cortical responsiveness caused by MD is reversed when binocular visual experience follows temporary anesthetic inactivation of the retinas. In 3-mo-old kittens, we show that a severe impairment of visual acuity is also fully reversed by binocular experience following treatment and, further, that prolonged retinal inactivation alone can erase anatomical consequences of MD. We conclude that temporary retinal inactivation represents a highly efficacious means to promote recovery of function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.