ArticleProceedings of the National Academy of Sciences of the United States of America2016
Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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Who cites it
23 citing papers in PubMed.
- Volatile anaesthetics modulate voltage-gated sodium channel function at a site directly linked to channel gating.Nature communications · 2026Article
- Preorganized Electric Fields in Voltage-Gated Sodium Channels.Chembiochem : a European journal of chemical biology · 2025Article
- An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium Channels.ACS chemical neuroscience · 2021Article
- Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.Frontiers in cellular neuroscience · 2020Article
- Article
- Binding of the general anesthetic sevoflurane to ion channels.PLoS computational biology · 2018Article
- Propofol's paradox, explained.The Journal of general physiology · 2018Article
- Propofol inhibits prokaryotic voltage-gated NaThe Journal of general physiology · 2018Article
- Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.The Journal of general physiology · 2018Article
- Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.The Journal of biological chemistry · 2018Article
- Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.Biochimica et biophysica acta. Biomembranes · 2018Review
- Current NMR Techniques for Structure-Based Drug Discovery.Molecules (Basel, Switzerland) · 2018Review
- Solution NMR Studies of Anesthetic Interactions with Ion Channels.Methods in enzymology · 2018Article
- Recent progress on the molecular pharmacology of propofol.F1000Research · 2018Review
- X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels.Methods in enzymology · 2018Article
- Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.European biophysics journal : EBJ · 2017Review
- Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins.Scientific reports · 2017Article
- Isoflurane modulates activation and inactivation gating of the prokaryotic NaThe Journal of general physiology · 2017Article
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Authors and funding
11 authors.
Monica N KindeDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Vasyl BondarenkoDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Daniele GranataInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122.
Weiming BuDepartment of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Kimberly C GrastyDepartment of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102.
Patrick J LollDepartment of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102.
Vincenzo CarnevaleInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122.
Michael L KleinInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA 19122; mlklein@temple.edu xuy@anes.upmc.edu.
Roderic G EckenhoffDepartment of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Pei TangDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Yan XuDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; mlklein@temple.edu xuy@anes.upmc.edu.ORCID 0000-0003-2773-8024
Funding
X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ECKENHOFF, RODERIC G · 1997 to 2017
$22.4MNMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIAR37GM049202 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XU, YAN · 2004 to 2013
$4.9MResearch Training in Anesthesiology and Pain MedicineT32GM075770 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YAN XU · 2007 to 2026
$4.8MANESTHETIC SITES IN TRANSMEMBRANE PEPTIDES BY NMRR01GM056257 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 1998 to 2017
$4.8MNMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIAR01GM049202 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XU, YAN · 2000 to 2018
$3.3MAnesthetic Sites in Transmembrane Peptides by NMRR56GM056257 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 2008 to 2008
$391kNIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM049202NIGMS NIH HHS R01 GM056257NIGMS NIH HHS R37 GM049202NIGMS NIH HHS R56 GM056257NIGMS NIH HHS T32 GM075770
Abstract
Voltage-gated sodium channels (Na
Indexed as
Binding SitesBiophysical PhenomenaFluorineIon Channel GatingIonsIsofluraneKineticsMagnetic Resonance SpectroscopySodiumVoltage-Gated Sodium ChannelsFluorineIonsIsofluraneSodiumVoltage-Gated Sodium Channelsdrug–protein interactiongeneral anestheticsmolecular dynamics simulationnuclear magnetic resonancevoltage-gated sodium channel
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.