ArticleProceedings of the National Academy of Sciences of the United States of America2016
Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Using Organoids to Tap Mammary Gland Diversity for Novel Insight.Journal of mammary gland biology and neoplasia · 2024Review
- Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken.Development (Cambridge, England) · 2022Article
- Sequential inGenes & development · 2021Article
- Induction of a chromatin boundary in vivo upon insertion of a TAD border.PLoS genetics · 2021Article
- The molecular basis of mammary gland development and epithelial differentiation.Seminars in cell & developmental biology · 2021Review
- Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae.Molecular biology and evolution · 2021Article
- Regulatory Landscapes ofCirculation research · 2021Article
- Chromatin topology and the timing of enhancer function at theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mammalian-specific ectodermal enhancers control the expression ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha.Molecular biology and evolution · 2019Article
- Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.BMC biology · 2019Article
- TheGenes & development · 2017Article
- Control of growth and gut maturation byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock.Genes & development · 2017Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hoxd9, two genes of the HoxD complex, are transcribed during mammary bud (MB) development. However, unlike in other developmental contexts, their coexpression does not rely on the same regulatory mechanism. Hoxd8 is regulated by the combined activity of closely located sequences and the most distant telomeric gene desert. On the other hand, Hoxd9 is controlled by an enhancer-rich region that is also located within the telomeric gene desert but has no impact on Hoxd8 transcription, thus constituting an exception to the global regulatory logic systematically observed at this locus. The latter DNA region is also involved in Hoxd gene regulation in other contexts and strongly interacts with Hoxd9 in all tissues analyzed thus far, indicating that its regulatory activity was already operational before the appearance of mammary glands. Within this DNA region and neighboring a strong limb enhancer, we identified a short sequence conserved in therian mammals and capable of enhancer activity in the MBs. We propose that Hoxd gene regulation in embryonic MBs evolved by hijacking a preexisting regulatory landscape that was already at work before the emergence of mammals in structures such as the limbs or the intestinal tract.
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