Evidence map›Paper›PMID 27856714›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2017

Nasal high flow reduces dead space.

Winfried Möller, Sheng Feng, Ulrike Domanski, Karl-Josef Franke, Gülnaz Celik, Peter Bartenstein, Sven Becker, Gabriele Meyer, Otmar Schmid, Oliver Eickelberg and 2 more

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 129 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 11 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03282552 nacompletednot on this map

High Flow Oxygen Therapy Versus Conventional Oxygen Therapy in Cardiac Surgery Patients-OPTICAR Study

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2017 to 2019Enrolled99ConditionsHypoxemic Respiratory FailureArmsNasal Cannula High Flow Oxygen
NCT05291117 completednot on this mapstarted 2022, after this paper: background citation

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Apnoeic Ventilation During Operative Hysteroscopic Procedures Under General Anesthesia: an Observational Study.

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2022 to 2022Enrolled30ConditionsOxygen, General Anesthesia, Hysteroscopy
NCT05550584 nacompletednot on this mapstarted 2022, after this paper: background citation

High Flow Oxygen During ProcEdural Sedation for Operative Hysteroscopy: a Randomized Controlled Trial - HOPE Study.

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2022 to 2023Enrolled180ConditionsEndometrium, Hypertrophy, Cervix, Anesthesia, Apnea, PostanestheticArmsTransnasal humidified rapid-insufflation ventilatory exchange (THRIVE)., LMA
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 11 syntheses or guidelines pooled it, 252 citations in OpenAlex.

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  11. High-flow nasal cannulaTherapeutic advances in respiratory disease
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Winfried MöllerComprehensive Pneumology Center, German Center for Lung Research, Munich, Germany; moeller@helmholtz-muenchen.de.ORCID 0000-0003-3072-1346
Sheng FengFisher & Paykel Healthcare, Auckland, New Zealand.
Ulrike DomanskiHELIOS Klinik Hagen-Ambrock, Witten-Herdecke University, Hagen, Germany.
Karl-Josef FrankeHELIOS Klinik Hagen-Ambrock, Witten-Herdecke University, Hagen, Germany.
Gülnaz CelikComprehensive Pneumology Center, German Center for Lung Research, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, LMU Medical Center Grosshadern, Munich, Germany.
Sven BeckerDepartment of Otolaryngology, Head and Neck Surgery, LMU Medical Center Grosshadern, Munich, Germany.
Gabriele MeyerDepartment of Nuclear Medicine, Asklepios Fachkliniken München-Gauting, Gauting, Germany; and.
Otmar SchmidComprehensive Pneumology Center, German Center for Lung Research, Munich, Germany.
Oliver EickelbergComprehensive Pneumology Center, German Center for Lung Research, Munich, Germany.
Stanislav TatkovFisher & Paykel Healthcare, Auckland, New Zealand.
Georg NiliusHELIOS Klinik Hagen-Ambrock, Witten-Herdecke University, Hagen, Germany.
Helmholtz Zentrum München · DEWitten/Herdecke University · DEFisher & Paykel Healthcare (New Zealand) · NZLMU Klinikum · DEAsklepios Fachkliniken München-Gauting · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies show that nasal high flow (NHF) therapy can support ventilation in patients with acute or chronic respiratory disorders. Clearance of dead space has been suggested as being the key mechanism of respiratory support with NHF therapy. The hypothesis of this study was that NHF in a dose-dependent manner can clear dead space of the upper airways from expired air and decrease rebreathing. The randomized crossover study involved 10 volunteers using scintigraphy with NEW & NOTEWORTHY: Clearance of expired air in upper airways by nasal high flow (NHF) can be extended below the soft palate and de facto causes a reduction of dead space. Using scintigraphy, the authors found a relationship between NHF, time, and clearance. Direct measurement of CO

Indexed as

Carbon DioxideCross-Over StudiesFemaleHumansMaleMiddle AgedNasal CavityNasal MucosaNoseOxygenPulmonary VentilationRespirationRespiratory Dead SpaceTidal VolumeTracheaCarbon DioxideOxygendead spaceKryptonnasal high flowrebreathingrespiratory supportupper airways

Identifiers

PMID27856714
PMCPMC5283847
OpenAlexW2554126351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.