ArticleG3 (Bethesda, Md.)2017
First in Vivo Batrachochytrium dendrobatidis Transcriptomes Reveal Mechanisms of Host Exploitation, Host-Specific Gene Expression, and Expressed Genotype Shifts.
Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Host and Environmental Factors Outweigh Pathogen in Shaping Skin Microbiome of a Threatened Andean Amphibian Community.Molecular ecology · 2026Article
- Article
- Eukaryotic metagenome-assembled genomes recovered from deep metagenomic sequencing of the seagrass,Microbial genomics · 2026Article
- Using fluorescent in vitro amphibian cell infection models to quantify pathogenicity of Batrachochytrium dendrobatidis.Methods (San Diego, Calif.) · 2026Article
- Glutathione Impacts Both Batrachochytrium dendrobatidis Virulence and Amphibian Cellular Defense in a Chytridiomycosis Model.MicrobiologyOpen · 2026Article
- Glutathione impacts bothbioRxiv : the preprint server for biology · 2026Article
- Single-cell genomics, metagenomics, and transcriptomics ofAquatic ecology · 2026Article
- Comparative Genomics Reveals Intra and Inter Species Variation in the Pathogenic Fungus Batrachochytrium dendrobatidis.Genome biology and evolution · 2025Article
- Stable in vitro fluorescence for enhanced live imaging of infection models for Batrachochytrium dendrobatidis.PloS one · 2024Article
- Immune priming prior to pathogen exposure sheds light on the relationship between host, microbiome and pathogen in disease.Royal Society open science · 2023Article
- A Call for a Better Understanding of Aquatic Chytrid Biology.Frontiers in fungal biology · 2021Article
- Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections.Life (Basel, Switzerland) · 2020Review
- Experimental methodologies can affect pathogenicity of Batrachochytrium salamandrivorans infections.PloS one · 2020Article
- Reference gene screening of Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans for quantitative real-time PCR studies.Scientific reports · 2019Article
- Article
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5 authors.
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Abstract
For generalist pathogens, host species represent distinct selective environments, providing unique challenges for resource acquisition and defense from host immunity, potentially resulting in host-dependent differences in pathogen fitness. Gene expression modulation should be advantageous, responding optimally to a given host and mitigating the costs of generalism. Batrachochytrium dendrobatidis (Bd), a fungal pathogen of amphibians, shows variability in pathogenicity among isolates, and within-strain virulence changes rapidly during serial passages through artificial culture. For the first time, we characterize the transcriptomic profile of Bd in vivo, using laser-capture microdissection. Comparison of Bd transcriptomes (strain JEL423) in culture and in two hosts (Atelopus zeteki and Hylomantis lemur), reveals >2000 differentially expressed genes that likely include key Bd defense and host exploitation mechanisms. Variation in Bd transcriptomes from different amphibian hosts demonstrates shifts in pathogen resource allocation. Furthermore, expressed genotype variant frequencies of Bd populations differ between culture and amphibian skin, and among host species, revealing potential mechanisms underlying rapid changes in virulence and the possibility that amphibian community composition shapes Bd evolutionary trajectories. Our results provide new insights into how changes in gene expression and infecting population genotypes can be key to the success of a generalist fungal pathogen.
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