ArticleJournal of the Pediatric Infectious Diseases Society2016
Associations of Memory and Executive Functioning With Academic and Adaptive Functioning Among Youth With Perinatal HIV Exposure and/or Infection.
Article in Journal of the Pediatric Infectious Diseases Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01418014 (Adolescent Master Protocol), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Master Protocol
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- School functioning of children with perinatal HIV-infection in high-income countries: A systematic review.PloS one · 2021Pooled it
- In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes.Journal of the International AIDS Society · 2019Pooled it
- A systematic review of prospective memory in HIV disease: from the laboratory to daily life.The Clinical neuropsychologist · 2018Pooled it
- Tablet-Based Neurocognitive Tests for Ugandan Adolescents Living With HIV: Cross-Sectional Validation Study.JMIR mHealth and uHealth · 2026Article
- Cognitive Functioning and Its Stability Among Young Adults with Perinatal HIV Exposure or Acquisition in a U.S.-Based Longitudinal Cohort Study.AIDS and behavior · 2026Article
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone.Frontiers in molecular neuroscience · 2024Article
- Adaptation and construct validity evaluation of a tablet-based, short neuropsychological test battery for use with adolescents and young adults living with HIV in Thailand.Neuropsychology · 2022Article
- Ageing with HIV: a longitudinal study of markers of resilience in young adults with perinatal exposure to HIV, with or without perinatally acquired HIV.Journal of the International AIDS Society · 2022Article
- Central Nervous System Impact of Perinatally Acquired HIV in Adolescents and Adults: an Update.Current HIV/AIDS reports · 2022Review
- Mental health and adaptive functioning among school-aged children living with HIV in Zambia.Frontiers in psychiatry · 2022Article
- Learning and memory function in young people with and without perinatal HIV in England.PloS one · 2022Article
- Reduced neuronal population in the dorsolateral prefrontal cortex in infant macaques infected with simian immunodeficiency virus (SIV).Journal of neurovirology · 2021Article
- Neuropsychological and Psychosocial Functioning of Children with Perinatal HIV-Infection in The Netherlands.Viruses · 2021Article
- The relationship between executive function, risky behaviour and HIV in young women from the HPTN 068 study in rural South Africa.AIDS care · 2021Article
- Neurodevelopment of HIV-Exposed Uninfected Infants Born to Women With Perinatally Acquired HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed But Uninfected Compared to Those HIV-Unexposed and to Children Living With HIV.New directions for child and adolescent development · 2020Article
- Article
- Growth and Neurodevelopment of HIV-Exposed Uninfected Children: a Conceptual Framework.Current HIV/AIDS reports · 2019Review
- Impact of Perinatally Acquired HIV Disease Upon Longitudinal Changes in Memory and Executive Functioning.Journal of acquired immune deficiency syndromes (1999) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundPerinatally acquired HIV (PHIV) confers risk for neurocognitive impairment, which potentially affects school performance and functional independence of infected children. In this study, we examined the associations of 2 key neurocognitive domains, memory and executive function (EF), with academic and adaptive skills among youth with PHIV and perinatally HIV-exposed but uninfected (PHEU) youth.
methodsParticipants ages 9 to <19 years enrolled in the Pediatric HIV/AIDS Cohort Study's Memory and Executive Functioning Study completed standardized measures of reading and math. The primary caregivers completed a standardized measure of their child's adaptive behavior. Participants with PHIV, those with (PHIV/C) and without (PHIV/non-C) a Centers for Disease Control and Prevention class C diagnosis, and PHEU participants were compared. Retrospective memory (RM), prospective memory (PM), and EF were evaluated relative to outcomes using general linear regression models adjusted for sociodemographic characteristics.
resultsOf the participants (N = 258; mean age, 14.1 years), 46% were male, 75% were black, and 18% were Hispanic. Adjusted mean scores in math and adaptive behavior did not differ among the youth with PHIV/C (n = 45), those with PHIV/non-C (n = 128), and PHEU youth (n = 85). Youth with PHIV/C had lower adjusted mean reading scores than PHIV/non-C and PHEU youth (86.9 vs 93.8 [P = .02] and 93.2 [P = .04], respectively). There were positive associations of RM, PM, EF, and some sociodemographic characteristics with higher reading and math scores. Immediate and delayed verbal memory, delayed visual memory, PM, and some EF measures were positively associated with adaptive behavior.
conclusionsHigher-order cognitive abilities such as memory and EF seem to play a key role in academic and adaptive capacities, regardless of a child's HIV status, and might serve as intervention targets for improving functional outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.