Evidence map›Paper›PMID 27856611›Full record

ArticleCardiovascular research2017

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.

Lei Li, Jing Li, Benjamin M Drum, Yi Chen, Haifeng Yin, Xiaoyun Guo, Stephen W Luckey, Merle L Gilbert, G Stanley McKnight, John D Scott and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

  1. β-Adrenergic Receptors: Not Always Outside-In.Physiology (Bethesda, Md.) · 2026
    Review
  2. CaInflammation and regeneration · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Lei LiDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Jing LiDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Benjamin M DrumDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Yi ChenDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Haifeng YinDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Xiaoyun GuoDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
Stephen W LuckeyDepartment of Biology, Seattle University, 901 12th Ave., Seattle, WA 98122, USA.
Merle L GilbertDepartment of Pharmacology, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
G Stanley McKnightDepartment of Pharmacology, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
John D ScottDepartment of Pharmacology, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.
L Fernando SantanaDeparment of Physiology & Membrane Biology, University of California, One Shields Ave., Davis, CA 95616, USA.
Qinghang LiuDepartment of Physiology and Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA; qcliu@u.washington.edu.
University of Washington · USHoward Hughes Medical Institute · USSeattle University · USUniversity of California, Davis · US

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
Project# 4: INTERACTIONS OF ANCHORING PROTEINS WITH THEIR TARGETSP01DK054441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, SUSAN S. · 1999 to 2017
$27.3M
CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2M
REGULATION OF CYCLIC AMP-DEPENDENT PROTEIN KINASE GENESR01GM032875 · NIGMS · UNIVERSITY OF WASHINGTON · PI MCKNIGHT, GEORGE STANLEY · 1985 to 2017
$6.0M
NFAT-induced Regional Variations in Kv4 Channel Expression in HeartR01HL085686 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2020
$5.7M
A Critical TAK1 Signaling Network in Myocardial Survival and RemodelingR01HL116507 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIU, QINGHANG · 2013 to 2017
$1.9M
Local Signaling in Diabetic ComorbiditiesR01DK105542 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2015 to 2018
$1.4M
Role of TAK1 Signaling Network in Cardiac HypertrophyR00HL098076 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIU, QINGHANG · 2011 to 2013
$735k
Elucidating the biogenesis and role of junctional sarcoplasmic reticulum motility in normal and pathological Ca2+ signalingF30HL126249 · NHLBI · UNIVERSITY OF WASHINGTON · PI DRUM, BENJAMIN · 2015 to 2018
$152k
NHLBI NIH HHS F30 HL126249NHLBI NIH HHS R00 HL098076NHLBI NIH HHS R01 HL085686NHLBI NIH HHS R01 HL116507NHLBI NIH HHS T32 HL007828NIDDK NIH HHS P01 DK054441NIDDK NIH HHS R01 DK105542NIGMS NIH HHS R01 GM032875NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

aimsImpaired Ca METHODS AND

resultsHere we examined how AKAP150 signalling complexes impact Ca

conclusionsThese findings define a critical role for AKAP150 in regulating Ca

Indexed as

Calcium SignalingVentricular FunctionVentricular RemodelingA Kinase Anchor ProteinsAnimalsCalcineurinCalcium-Binding ProteinsCardiomyopathy, DilatedCells, CulturedDisease Models, AnimalFibrosisGenetic Predisposition to DiseaseHeart FailureIsoproterenolMice, KnockoutMyocardial IschemiaAkap5 protein, mouseA Kinase Anchor ProteinsAtp2a2 protein, mouseCalcineurinCalcium-Binding ProteinsIsoproterenolNFATC Transcription FactorsPhospholambanryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesAKAP150Cardiac hypertrophyContractilityHeart failurePathological remodelling

Identifiers

PMID27856611
PMCPMC5340143
OpenAlexW2552554888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.