Evidence map›Paper›PMID 27856608›Full record

ArticleDiabetes2017

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes.

Goutham Vasam, Shrinidh Joshi, Sean E Thatcher, Stephen H Bartelmez, Lisa A Cassis, Yagna P R Jarajapu

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  10. Current Understanding of Osteoimmunology in Certain Osteoimmune Diseases.Frontiers in cell and developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Goutham VasamDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND.
Shrinidh JoshiDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND.
Sean E ThatcherDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY.
Stephen H BartelmezBetaStem Therapeutics, Inc., San Francisco, CA.
Lisa A CassisDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY.
Yagna P R JarajapuDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND yagna.jarajapu@ndsu.edu.
North Dakota State University · USUniversity of Kentucky · USBetaStem Therapeutics (United States) · US

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
Angiotensin: A Link Between Obesity and HypertensionR01HL073085 · NHLBI · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2003 to 2017
$5.0M
Pilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9M
NCRR NIH HHS U42 RR024244NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01 HG004085NHLBI NIH HHS R01 HL073085NIGMS NIH HHS P30 GM103332
6 · The paper itself

Abstract

The angiotensin (ANG)-(1-7)/Mas receptor (MasR) pathway activates vascular repair-relevant functions of bone marrow progenitor cells. We tested the effects of ANG-(1-7) on mobilization and vasoreparative functions of progenitor cells that are impaired in diabetes. The study was performed in streptozotocin-induced diabetic (db/db) mice. Diabetes resulted in a decreased number of Lineage

Indexed as

1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IAnimalsBlood VesselsBone MarrowBone Marrow CellsCell LineageCell MovementChemokine CXCL12Diabetes Mellitus, ExperimentalIschemiaMaleMembrane ProteinsMiceNeovascularization, PhysiologicPeptide Fragments1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin Iangiotensin I (1-7)Chemokine CXCL12Cxcl12 protein, mousefasudilMembrane ProteinsPeptide FragmentsProtein Kinase InhibitorsProto-Oncogene MasProto-Oncogene ProteinsReceptors, G-Protein-Coupledrho-Associated KinasesSlit3 protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVasodilator Agents

Identifiers

PMID27856608
PMCPMC5248994
OpenAlexW2550575508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.