ArticleAmerican journal of epidemiology2016
Sex-Specific and Time-Varying Associations Between Cigarette Smoking and Telomere Length Among Older Adults.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis.Environmental research · 2017Pooled it
- Proteomic Mendelian randomization to identify protein biomarkers of telomere length.Scientific reports · 2024Article
- Leukocyte telomere length and memory circuitry and cognition in early aging: Impact of sex and menopausal status.Hormones and behavior · 2024Article
- Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study.Journal of translational medicine · 2024Article
- Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease-induced neuropathological comorbidities.British journal of pharmacology · 2024Review
- Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors.Aging and disease · 2023Review
- Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults.Clinical epigenetics · 2022Article
- Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999-2002.Oxidative medicine and cellular longevity · 2022Article
- Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.Journal of clinical medicine · 2021Review
- Article
- Modifiable mediators associated with the relationship between adiposity and leukocyte telomere length in US adults: The National Health and Nutrition Examination Survey.Preventive medicine · 2020Article
- Cell senescence and fibrotic lung diseases.Experimental gerontology · 2020Review
- Article
- Associations of smoking indicators and cotinine levels with telomere length: National Health and Nutrition Examination Survey.Preventive medicine reports · 2019Article
- Stress and Salivary Telomere Length in the Second Half of Life: A Comparison of Life-course Models.Advances in life course research · 2019Article
- Does Telomere Length Indicate Biological, Physical, and Cognitive Health Among Older Adults? Evidence from the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- A study of telomere length, arsenic exposure, and arsenic toxicity in a Bangladeshi cohort.Environmental research · 2018Article
- The association of sarcopenia, telomere length, and mortality: data from the NHANES 1999-2002.European journal of clinical nutrition · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Inconsistent associations between smoking and telomere length (TL) have been reported in epidemiologic studies, perhaps because of the time-varying nature of smoking behaviors. We estimated the associations of TL, which was measured by quantitative polymerase chain reaction using saliva DNA, with concurrent and past smoking status reported biennially for up to 16 years before TL measurement in 5,624 participants in the Health and Retirement Study (1992-2008). Smoking was associated with reduced TL when we used prospective data on smoking statuses among men and women, but the association was strongly attenuated among men in cross-sectional analyses. This attenuation was largely due to a higher rate of smoking cessation during the study period among men with shorter TL than among men with longer TL. Short TL was also associated with poorer overall health in men, which suggests that male smokers with short TL were more likely to quit smoking because of poor health. Analyses of years since cessation, smoking duration, and pack-years of smoking all support the hypothesis that increased cigarette use shortens TL. Our results provide a potential explanation for the inconsistent associations between smoking and TL reported in previous cross-sectional studies. Time-varying associations should be considered in future studies of smoking behavior, TL, aging, and disease risk.
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