ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2017
Methodological issues in the use of individual brain measures to index trait liabilities: The example of noise-probe P3.
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry When Biology Could Be Associated With Both Symptoms and Syndromes.Biological psychiatry · 2026Review
- Opposing Relations of Reward Positivity with Anhedonia and Threat Sensitivity: Implications for Differential Dimensional Diagnosis.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Clarifying the place of p300 in the empirical structure of psychopathology over development.Journal of psychopathology and clinical science · 2024Article
- Pain processing and antisocial behavior: A multimodal investigation of the roles of boldness and meanness.Personality disorders · 2022Article
- Internal consistency and test-retest reliability of the P3 event-related potential (ERP) elicited by alcoholic and non-alcoholic beverage pictures.Psychophysiology · 2022Article
- Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.Journal of abnormal psychology · 2021Article
- Back to Basics: The Importance of Measurement Properties in Biological Psychiatry.Neuroscience and biobehavioral reviews · 2021Review
- Using a co-twin control design to evaluate alternative trait measures as indices of liability for substance use disorders.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them.Psychological assessment · 2019Review
- Multidimensional assessment of impulsivity-related measures in relation to externalizing behaviors.Psychological medicine · 2019Article
- Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project.Assessment · 2019Article
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Authors and funding
6 authors.
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Abstract
Recent research initiatives have called for an increased use of biological concepts and measures in defining and studying mental health problems, but important measurement-related challenges confront efforts in this direction. This article highlights some of these challenges with reference to an intriguing measure of neural reactivity: the probe P3 response, a mid-latency brain potential evoked by an intense, unexpected acoustic-probe stimulus. Using data for a large adult sample (N=418), we report evidence that amplitude of probe P3 response to unwarned noise bursts occurring in a picture-viewing task exhibits robust, independent associations with two distinct trait constructs: weak inhibitory control (or disinhibition; DIS) and threat sensitivity (THT). Additionally, we report a selective association for THT with attentional suppression of probe P3 response during viewing of aversive pictures compared to neutral. These results point to separable elements of variance underlying the probe P3 response, including one element reflecting DIS-related variations in cognitive-elaborative processing, and others reflecting THT-related variations in aversive foreground engagement and abrupt defensive reorientation. Key measurement issues are considered in relation to these specific findings, and methodological and statistical approaches for addressing these issues are discussed in relation to advancement of a quantitatively sound, biologically informed science of psychopathology.
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