Evidence map›Paper›PMID 27856360›Full record

ArticleNeurotoxicology and teratology

Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3

Changsheng Li, Michele Schaefer, Christy Gray, Ya Yang, Orion Furmanski, Sufang Liu, Paul Worley, C David Mintz, Feng Tao, Roger A Johns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Changsheng LiDepartment of Anesthesiology, Affiliated Anti-cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province 450008, China; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Michele SchaeferDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christy GrayDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ya YangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Orion FurmanskiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sufang LiuDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Basic Medical School of Zhengzhou University, Zhengzhou, Henan Province 450001, China.
Paul WorleyDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
C David MintzDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Feng TaoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Anesthesiology and Critical Care Medicine, Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX 75246, USA.
Roger A JohnsDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: rajohns@jhmi.edu.
Johns Hopkins Medicine · USZhengzhou University · CNBaylor University · USJohns Hopkins University · US

Funding

Program in Postdoctoral Research Training in AnesthesiologyT32GM075774 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SAPNA R KUDCHADKAR, Emmett E Whitaker · 2006 to 2026
$8.1M
Targeting PDZ to unravel early anesthetic exposure-produced cognitive dysfunctionR01GM110674 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2014 to 2023
$3.5M
NO SIGNALING IN MECHANISMS OF ANALGESIA AND ANESTHESIAR01GM049111 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOHNS, ROGER A · 1993 to 2009
$3.0M
Mechanisms of Developmental Anesthesia ToxicityR01GM120519 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MINTZ, CYRUS DAVID · 2016 to 2020
$2.1M
Gender differences in stress-induced pain transition after surgeryR01DE022880 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI TAO, FENG · 2012 to 2016
$2.0M
Targeting resitin and RELM-beta to treat pulmonary hypertensionP50HL107182 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JOHNS, ROGER A · 2011 to 2012
$983k
A new animal model for stress-induced transition from acute to chronic painK02DE023551 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI TAO, FENG · 2014 to 2018
$564k
NHLBI NIH HHS P50 HL107182NIDCR NIH HHS K02 DE023551NIDCR NIH HHS R01 DE022880NIGMS NIH HHS R01 GM049111NIGMS NIH HHS R01 GM110674NIGMS NIH HHS R01 GM120519NIGMS NIH HHS T32 GM075774
6 · The paper itself

Abstract

Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some patients with autism or specific autism spectrum disorders (ASD) exhibit altered responses to pain and to anesthesia or sedation. A genetic mouse model of one particular ASD, Phelan McDermid Syndrome, has been developed that has a Shank3 haplotype truncation (Shank3

Indexed as

AnimalsAutism Spectrum DisorderDisks Large Homolog 4 ProteinDose-Response Relationship, DrugIsofluraneMaleMiceMicrofilament ProteinsMutationNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateReflex, RightingRotarod Performance TestSpinal CordVestibular NucleiDisks Large Homolog 4 ProteinDlg4 protein, mouseGprin1 protein, mouseIsofluraneMicrofilament ProteinsNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateShank3 protein, mouseAutism Spectrum DisorderIsofluraneNR1PSD95Shank3

Identifiers

PMID27856360
PMCPMC5871225
OpenAlexW2551054138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.