Trial reportJournal of the American Society of Hypertension : JASH2016
Total antihypertensive therapeutic intensity score and its relationship to blood pressure reduction.
Trial report in Journal of the American Society of Hypertension : JASH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Semaglutide and blood pressure: an individual patient data meta-analysis.European heart journal · 2024 · on this mapPooled it
- Impact of first-line antihypertensive drug class and intensity on NT-proBNP improvement and cardiovascular outcomes among hypertensive patients with pre-heart failure: findings from SPRINT trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Antihypertensive Medication Regimens Used in the Systolic Blood Pressure Intervention Trial.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- Does Vitamin D Provide Added Benefit to Antihypertensive Therapy in Reducing Left Ventricular Hypertrophy Determined by Cardiac Magnetic Resonance?American journal of hypertension · 2023Trial
- Integration of a multicomponent intervention for hypertension into primary healthcare services in Singapore-A cluster randomized controlled trial.PLoS medicine · 2022Trial
- Effect of a Multicomponent Intervention on Antihypertensive Medication Intensification in Rural South Asia: Post Hoc Analysis of a Cluster RCT.American journal of hypertension · 2021Trial
- Angiotensin-converting enzyme inhibitors increase anti-fibrotic biomarkers in African Americans with left ventricular hypertrophy.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- Effect of Lower Blood Pressure Goals on Left Ventricular Structure and Function in Patients With Subclinical Hypertensive Heart Disease.American journal of hypertension · 2020Trial
- Prevalence and clinical correlates of positive aldosterone-to-renin ratio screening in obese hypertensive patients with obstructive sleep apnea: a Southeast Asian cross-sectional study.Journal of human hypertension · 2026Article
- Renin-to-Aldosterone Ratio Is Associated with Ambulatory Blood Pressure Levels and Control in Treated Hypertensive Patients with Overweight or Obesity.Obesity facts · 2026Article
- Systemic blood pressure changes following coronary revascularization: towards a coronary baroreflex?European heart journal open · 2026Article
- Correlation between pharmacologic blood pressure-lowering intensity and improvement in cardiac function in patients with acutely decompensated heart failure.BMC cardiovascular disorders · 2026Article
- Combination of treatment intensity score and interankle diastolic blood pressure is associated with cardiovascular prognosis among adults with controlled hypertension who have pre-existing cardiovascular disease.Blood pressure monitoring · 2026Article
- Postpartum health-care utilization and blood pressure control by antihypertensive agent in hypertensive disorders of pregnancy.American journal of obstetrics & gynecology MFM · 2026Article
- Disparities in Initial Antihypertensive Intensity by Sex, Race and Ethnicity in Newly Treated Patients With Hypertension.American journal of hypertension · 2025Article
- Triple Antihypertensive Medication Prediction Score After Intracerebral Hemorrhage (the TRICH Score).Neurology · 2025Article
- A composite score of polygraphic oximetry parameters predicts left ventricular hypertrophy in patients with obstructive sleep apnoea.ERJ open research · 2025Article
- Hypertension in obstructive sleep apnea: the hidden role of renin-angiotensin-aldosterone system dysregulation.Tropical medicine and health · 2025Article
- Practice-Pattern Variation in Neurocritical Care Blood Pressure Control Reveals Opportunities for Improved Long-Term Hypertension Control.Neurology. Clinical practice · 2025Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Predicting blood pressure (BP) response to antihypertensive therapy is challenging. The therapeutic intensity score (TIS) is a summary measure that accounts for the number of medications and the relative doses a patient received, but its relationship to BP change and its utility as a method to project dosing equivalence has not been reported. We conducted a prospective, single center, randomized controlled trial to compare the effects of Joint National Committee (JNC) 7 compliant treatment with more intensive (<120/80 mm Hg) BP goals on left ventricular structure and function in hypertensive patients with echocardiographically determined subclinical heart disease who were treated over a 12-month period. For this preplanned subanalysis, we sought to compare changes in BP over time with changes in TIS. Antihypertensive therapy was open label. TIS and BP were determined at 3-month intervals with titration of medication doses as needed to achieve targeted BP. Mixed linear models defined antihypertensive medication TIS as an independent variable and change in systolic BP as an outcome measure, while controlling for gender, age, baseline BP, and treatment group. A total of 123 patients (mean age 49.4 ± 8.2 years; 66% female; 95.1% African-American) were enrolled and 88 completed the protocol. For each single point increase in total antihypertensive TIS, a 14.5 (95% confidence interval: 11.5, 17.4) mm Hg decrease in systolic BP was noted (15.5 [95% confidence interval: 13.0, 18.0] mm Hg for those who completed the trial). Total TIS is a viable indicator of the anticipated BP-lowering effect associated with antihypertensive therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.