Evidence map›Paper›PMID 27855871›Full record

SynthesisThe Lancet. Global health2016

Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis.

Elima Jedy-Agba, Valerie McCormack, Clement Adebamowo, Isabel Dos-Santos-Silva

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Global health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 19 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 19 syntheses or guidelines pooled it, 383 citations in OpenAlex.

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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Elima Jedy-AgbaDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Institute of Human Virology, Abuja, Nigeria.
Valerie McCormackSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Clement AdebamowoDepartment of Epidemiology and Public Health, University of Maryland Marlene and Stewart Greenebaum Comprehensivew Cancer Center, Baltimore, MD, USA; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Isabel Dos-Santos-SilvaDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: isabel.silva@lshtm.ac.uk.
London School of Hygiene & Tropical Medicine · GBCentre International de Recherche sur le Cancer · FRUniversity of Maryland, Baltimore · US

Funding

Training Program in Nigeria for NCD Research (TRAPING - NCD)D43TW009106 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI ADEBAMOWO, CLEMENT ADEBAYO · 2011 to 2015
$1.1M
FIC NIH HHS D43 TW009106World Health Organization 001
6 · The paper itself

Abstract

backgroundThe incidence of breast cancer in sub-Saharan Africa is relatively low, but as survival from the disease in the region is poor, mortality rates are as high as in high-income countries. Stage at diagnosis is a major contributing factor to poor survival from breast cancer. We aimed to do a systematic review and meta-analysis on stage at diagnosis of breast cancer in sub-Saharan Africa to examine trends over time, and investigate sources of variations across the region.

methodsWe searched MEDLINE, Embase, Web of Knowledge, and Africa-Wide Information to identify studies on breast cancer stage at diagnosis in sub-Saharan African women published before Jan 1, 2014, and in any language. Random-effects meta-analyses were done to investigate between-study heterogeneity in percentage of late-stage breast cancer (stage III/IV), and meta-regression analyses to identify potential sources of variation. Percentages of women with late-stage breast cancer at diagnosis in sub-Saharan Africa were compared with similar estimates for black and white women in the USA from the Surveillance, Epidemiology, and End Results database.

findings83 studies were included, which consisted of 26 788 women from 17 sub-Saharan African countries. There was wide between-study heterogeneity in the percentage of late-stage disease at diagnosis (median 74·7%, range 30·3-100%, I

interpretationStrategies for early diagnosis of breast cancer should be regarded as a major priority by cancer control programmes in sub-Saharan Africa.

fundingNone.

Indexed as

Neoplasm StagingAfrica South of the SaharaBlack PeopleBreast NeoplasmsHumansIncidenceWomen's Health

Identifiers

PMID27855871
PMCPMC5708541
OpenAlexW2556079332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.