Evidence map›Paper›PMID 27855806›Full record

ArticleJournal of the American College of Cardiology2016

Long-Term Prognostic Value of Cardiac Magnetic Resonance in Left Ventricle Noncompaction: A Prospective Multicenter Study.

Daniele Andreini, Gianluca Pontone, Jan Bogaert, Alberto Roghi, Andrea Barison, Juerg Schwitter, Saima Mushtaq, Georgios Vovas, Paola Sormani, Giovanni D Aquaro and 14 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Guideline
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  15. Mitral Annular Disjunction and Coalescing Myths in Cardiology.Arrhythmia & electrophysiology review · 2026
    Article
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  20. Observational

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 3 countries.

Daniele AndreiniCentro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. Electronic address: daniele.andreini@ccfm.it.
Gianluca PontoneCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Jan BogaertGasthuisberg University Hospital, Leuven, Belgium.
Alberto RoghiNiguarda Cà Granda Hospital, Milan, Italy.
Andrea BarisonNiguarda Cà Granda Hospital, Milan, Italy.
Juerg SchwitterCentre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland.
Saima MushtaqCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Georgios VovasGasthuisberg University Hospital, Leuven, Belgium.
Paola SormaniNiguarda Cà Granda Hospital, Milan, Italy.
Giovanni D AquaroFondazione CNR-Regione Toscana 'G.Monasterio,' Pisa, Italy.
Pierre MonneyCentre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland.
Chiara SeguriniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Marco GuglielmoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Edoardo ConteCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Laura FusiniCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Antonio Dello RussoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Massimo LombardiMultimodality Cardiac Imaging Section, Policlinico San Donato, Milan, Italy.
Paola GripariCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Andrea BaggianoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Cesare FiorentiniCentro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
Federico LombardiDepartment of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy; Department of Cardiovascular Disease, Ospedale Maggiore Policlinico, Milan, Italy.
Antonio L BartorelliCentro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco," University of Milan, Milan, Italy.
Mauro PepiCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Pier Giorgio MasciCentre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland.
Centro Cardiologico Monzino · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITUniversity Hospital of Lausanne · CHUniversitair Ziekenhuis Leuven · BEUniversity of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFondazione Toscana Gabriele Monasterio · ITIRCCS Policlinico San Donato · ITLuigi Sacco Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value.

objectivesThe goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC.

methodsA total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m

resultsAt a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE.

conclusionsIn patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.

Indexed as

AdultDisease ProgressionEchocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansIsolated Noncompaction of the Ventricular MyocardiumMagnetic Resonance Imaging, CineMaleMiddle AgedPrognosisProspective StudiesReproducibility of ResultsTime Factorscardiac magnetic resonancedilated cardiomyopathylate gadolinium enhancementleft ventricular noncompactionprognosis

Identifiers

PMID27855806
OpenAlexW2556747787

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.