ArticleJournal of the American College of Cardiology2016
Left Ventricular Noncompaction: Anatomical Phenotype or Distinct Cardiomyopathy?
Article in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Guideline
- Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Pooled it
- Mitral Annular Disjunction and Coalescing Myths in Cardiology.Arrhythmia & electrophysiology review · 2026Article
- Longitudinal strain in left ventricular non-compaction: insights derived from two-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging strain.BMC cardiovascular disorders · 2025Article
- Preliminary investigation into the mechanical implications of excessive trabecularization in the left ventricle.Quantitative imaging in medicine and surgery · 2025Article
- Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024Review
- ABLE-SCORE, a simplified risk score for major adverse cardiovascular outcomes in left ventricular hypertrabeculation: a multicenter longitudinal cohort study.BMC medicine · 2024Observational
- Genetic, clinical and imaging implications of a noncompaction phenotype population with preserved ejection fraction.Frontiers in cardiovascular medicine · 2024Article
- Excessive Trabeculation of the Left Ventricle: JACC: Cardiovascular Imaging Expert Panel Paper.JACC. Cardiovascular imaging · 2023Review
- Clinical application of CMR in cardiomyopathies: evolving concepts and techniques : A position paper of myocardial and pericardial diseases and cardiac magnetic resonance working groups of Italian society of cardiology.Heart failure reviews · 2023Review
- Making Less of a Mess of the Trabecular Mesh.Radiology. Cardiothoracic imaging · 2022Article
- Characteristics and long-term survival of patients with left ventricular non-compaction cardiomyopathy.ESC heart failure · 2022Article
- Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes.iScience · 2022Article
- Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity-a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- Left Ventricular Non-Compaction Cardiomyopathy-Still More Questions than Answers.Journal of clinical medicine · 2022Review
- Left Ventricular Noncompaction in Children: The Role of Genetics, Morphology, and Function for Outcome.Journal of cardiovascular development and disease · 2022Review
- Correlation between left ventricular fractal dimension and impaired strain assessed by cardiac MRI feature tracking in patients with left ventricular noncompaction and normal left ventricular ejection fraction.European radiology · 2022Article
- Saw-Tooth Cardiomyopathy: the Evidence in the First Decade.Reviews in cardiovascular medicine · 2022Review
- Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation.Journal of anatomy · 2022Article
- State-of-the art review: Noncompaction cardiomyopathy in pediatric patients.Heart failure reviews · 2022Review
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThere is considerable overlap between left ventricular noncompaction (LVNC) and other cardiomyopathies. LVNC has been reported in up to 40% of the general population, raising questions about whether it is a distinct pathological entity, a remodeling epiphenomenon, or merely an anatomical phenotype.
objectivesThe authors determined the prevalence and predictors of LVNC in a healthy population using 4 cardiac magnetic resonance imaging diagnostic criteria.
methodsVolunteers >40 years of age (N = 1,651) with no history of cardiovascular disease (CVD), a 10-year risk of CVD < 20%, and a B-type natriuretic peptide level greater than their gender-specific median underwent magnetic resonance imaging scan as part of the TASCFORCE (Tayside Screening for Cardiac Events) study. LVNC ratios were measured on the horizontal and vertical long axis cine sequences. All individuals with a noncompaction ratio of ≥2 underwent short axis systolic and diastolic LVNC ratio measurements, and quantification of noncompacted and compacted myocardial mass ratios. Those who met all 4 criteria were considered to have LVNC.
resultsOf 1,480 participants analyzed, 219 (14.8%) met ≥1 diagnostic criterion for LVNC, 117 (7.9%) met 2 criteria, 63 (4.3%) met 3 criteria, and 19 (1.3%) met all 4 diagnostic criteria. There was no difference in demographic or allometric measures between those with and without LVNC. Long axis noncompaction ratios were the least specific, with current diagnostic criteria positive in 219 (14.8%), whereas the noncompacted to compacted myocardial mass ratio was the most specific, only being met in 61 (4.4%).
conclusionsA significant proportion of an asymptomatic population free from CVD satisfy all currently used cardiac magnetic resonance imaging diagnostic criteria for LVNC, suggesting that those criteria have poor specificity for LVNC, or that LVNC is an anatomical phenotype rather than a distinct cardiomyopathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.